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Characterization of the Cytochrome c Membrane-Binding Site Using Cardiolipin-Containing Bicelles with NMR
http://hdl.handle.net/10061/11025
http://hdl.handle.net/10061/11025b45c33bc-9672-4747-9bed-04fa1f72037e
名前 / ファイル | ライセンス | アクション |
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fulltext (4.2 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-10 | |||||
タイトル | ||||||
タイトル | Characterization of the Cytochrome c Membrane-Binding Site Using Cardiolipin-Containing Bicelles with NMR | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cytochrome c | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Bicellen | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Membranproteine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | NMR-Spektroskopie | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Protein-Lipid-Wechselwirkungen | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
著者 |
Kobayashi, Hisashi
× Kobayashi, Hisashi× Nagao, Satoshi× Hirota, Shun |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Cytochrome (cyt)?c transports electrons from Complex?III to Complex?IV in mitochondria. Cyt?c is ordinarily anchored to the mitochondrial membrane through interaction with cardiolipin (CL), however its release into the cytosol initiates apoptosis. The cyt?c interaction site with CL-containing bicelles was characterized by NMR spectroscopy. Chemical shift perturbations in cyt?c signals upon interaction with bicelles revealed that a relatively wide region, which includes the A-site, the CXXCH motif, and the N- and C-terminal helices, and contains multiple Lys residues, interacts cooperatively with CL. The specific cyt?c?CL interaction increased with increasing CL molecules in the bicelles. The location of the cyt?c interaction site for CL was similar to those for Complex?III and Complex?IV, thus indicating that cyt?c recognizes lipids and partner proteins in a similar way. In addition to elucidating the cyt?c membrane-binding site, these results provide insight into the dynamic aspect of cyt?c interactions in mitochondria. | |||||
書誌情報 |
en : Angewandte Chemie 発行日 2016-10-10 |
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出版者 | ||||||
出版者 | Wiley-VCH Verlag GmbH & Co | |||||
EISSN/PISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1521-3757 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 27723218 | |||||
出版者版DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1002/anie.201607419 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11614145 | |||||
権利 | ||||||
権利情報 | c 1999 - 2016 John Wiley & Sons, Inc. | |||||
権利 | ||||||
権利情報 | This is the accepted version of the following article:Characterization of the Cytochrome?c Membrane-Binding Site Using Cardiolipin-Containing Bicelles with NMR, Hisashi Kobayashi,Satoshi Nagao, Shun Hirota, Angewandte Chemie, Oct 10, 2016, which has been published in final form at http://dx.doi.org/10.1002/anie.201607419. | |||||
権利 | ||||||
権利情報 | 出版社許諾条件により本文は2017年10月10日以降公開。 | |||||
著者版フラグ | ||||||
出版タイプ | AM |