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Rational Design of Heterodimeric Protein using Domain Swapping for Myoglobin
http://hdl.handle.net/10061/10411
http://hdl.handle.net/10061/10411c6cd344f-eb39-4959-be7c-5e605e16052a
名前 / ファイル | ライセンス | アクション |
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fulltext (1.7 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2015-09-25 | |||||
タイトル | ||||||
タイトル | Rational Design of Heterodimeric Protein using Domain Swapping for Myoglobin | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | dimerization | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | heme coordination | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | heme proteins | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | salt bridges | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | X-ray crystallography | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
著者 |
Lin, Ying-Wu
× Lin, Ying-Wu× Nagao, Satoshi× Zhang, Mohan× Shomura, Yasuhito× Higuchi, Yoshiki× Hirota, Shun |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Protein design is a useful method to create novel artificial proteins. A rational approach to design a heterodimeric protein using domain swapping for horse myoglobin (Mb) was developed. As confirmed by X-ray crystallographic analysis, a heterodimeric Mb with two different active sites was produced efficiently from two surface mutants of Mb, in which the charges of two amino acids involved in the dimer salt bridges were reversed in each mutant individually, with the active site of one mutant modified. This study shows that the method of constructing heterodimeric Mb with domain swapping is useful for designing artificial multiheme proteins. | |||||
書誌情報 |
en : Angewandte Chemie International Edition 巻 54, 号 2, p. 511-515, 発行日 2014-11-04 |
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出版者 | ||||||
出版者 | WILEY-VCH Verlag | |||||
EISSN/PISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1521-3773 | |||||
出版者版DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1002/anie.201409267 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11614189 | |||||
権利 | ||||||
権利情報 | 出版社許諾条件により、本文は2015年11月4日以降公開 | |||||
権利 | ||||||
権利情報 | c 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the peer reviewed version of the following article: http://onlinelibrary.wiley.com/doi/10.1002/anie.201409267/full, which has been published in final form at http://dx.doi.org/10.1002/anie.201409267. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. | |||||
著者版フラグ | ||||||
出版タイプ | AM |