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Tesmin, Metallothionein-Like 5, is Required for Spermatogenesis in Mice
http://hdl.handle.net/10061/14028
http://hdl.handle.net/10061/140281b8347f2-1a60-40d4-85bd-db557139b34b
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-08-25 | |||||
| タイトル | ||||||
| タイトル | Tesmin, Metallothionein-Like 5, is Required for Spermatogenesis in Mice | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | knockout | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | male infertility | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | meiotic arrest | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | spermatogenesis | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Oji, Asami
× Oji, Asami× Isotani, Ayako× Fujihara, Yoshitaka× Castaneda, Julio M× Oura, Seiya× Ikawa?, Masahito |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In mammals, more than 2000 genes are specifically or abundantly expressed in testis, but gene knockout studies revealed several are not individually essential for male fertility. Tesmin (Metallothionein-like 5; Mtl5) was originally reported as a testis-specific transcript that encodes a member of the cysteine-rich motif containing metallothionein family. Later studies showed that Tesmin has two splicing variants and both are specifically expressed in male and female germ cells. Herein, we clarified that the long (Tesmin-L) and short (Tesmin-S) transcript forms start expressing from spermatogonia and the spermatocyte stage, respectively, in testis. Furthermore, while Tesmin-deficient female mice are fertile, male mice are infertile due to arrested spermatogenesis at the pachytene stage. We were able to rescue the infertility with a Tesmin-L transgene, where we concluded that TESMIN-L is critical for meiotic completion in spermatogenesis and indispensable for male fertility. | |||||
| 言語 | en | |||||
| 書誌情報 |
en : Biology of Reproduction 巻 102, 号 4, p. 975-983, 発行日 2020-04-15 |
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| 出版者 | ||||||
| 出版者 | Oxford University Press | |||||
| 言語 | en | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1529-7268 | |||||
| PubMed番号 | ||||||
| 関連タイプ | isReplacedBy | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 31916570 | |||||
| 出版者版DOI | ||||||
| 関連タイプ | isReplacedBy | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1093/biolre/ioaa002 | |||||
| 出版者版URI | ||||||
| 関連タイプ | isReplacedBy | |||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://academic.oup.com/biolreprod/article/102/4/975/5698627 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | c The Author(s) 2020. Published by Oxford University Press on behalf of Society for the Study of Reproduction. | |||||
