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Membrane-deformation ability of ANKHD1 is involved in the early endosome enlargement
http://hdl.handle.net/10061/13377
http://hdl.handle.net/10061/13377d5fea521-3ef4-4106-9564-c2078e2f9618
名前 / ファイル | ライセンス | アクション |
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Press release (587.4 kB)
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fulltext (11.0 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-09-17 | |||||
タイトル | ||||||
タイトル | Membrane-deformation ability of ANKHD1 is involved in the early endosome enlargement | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
著者 |
Kitamata, Manabu
× Kitamata, Manabu× Hanawa-Suetsugu, Kyoko× Maruyama, Kohei× Suetsugu, Shiro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Ankyrin-repeat domains (ARDs) are conserved in large numbers of proteins. ARDs are composed of various numbers of ankyrin repeats (ANKs). ARDs often adopt curved structures reminiscent of the Bin-Amphiphysin-Rvs (BAR) domain, which is the dimeric scaffold for membrane tubulation. BAR domains sometimes have amphipathic helices for membrane tubulation and vesiculation. However, it is unclear whether ARD-containing proteins exhibit similar membrane deformation properties. We found that the ARD of ankyrin repeat and KH domain-containing protein 1 (ANKHD1) dimerizes and deforms membranes into tubules and vesicles. Among 25 ANKs of ANKHD1, the first 15 ANKs can form a dimer, and the latter 10 ANKs enable membrane tubulation and vesiculation through an adjacent amphipathic helix and a predicted curved structure with a positively charged surface, analogous to BAR domains. Knockdown and localization of ANKHD1 suggested its involvement in the negative regulation of early endosome enlargement owing to its membrane vesiculation. | |||||
書誌情報 |
en : iScience 巻 17, p. 101-118, 発行日 2019-07-26 |
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出版者 | ||||||
出版者 | Elsevier (Cell Press) | |||||
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収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2589-0042 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 31255983 | |||||
出版者版DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1016/j.isci.2019.06.020 | |||||
権利 | ||||||
権利情報 | c 2019 The Author(s). | |||||
著者版フラグ | ||||||
出版タイプ | VoR |