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System identification of signaling dependent gene expression with different time-scale data
http://hdl.handle.net/10061/13116
http://hdl.handle.net/10061/13116ded5e717-6182-4d1f-95ac-c1f2fdec5c4c
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
fulltext (18.0 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2019-02-12 | |||||
| タイトル | ||||||
| タイトル | System identification of signaling dependent gene expression with different time-scale data | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 著者 |
Tsuchiya, Takaho
× Tsuchiya, Takaho× Fujii, Masashi× Kunida, Katsuyuki× Uda, Shinsuke× Kubota, Hiroyuki× Konishi, Katsumi× Kuroda, Shinya |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Cells decode information of signaling activation at a scale of tens of minutes by downstream gene expression with a scale of hours to days, leading to cell fate decisions such as cell differentiation. However, no system identification method with such different time scales exists. Here we used compressed sensing technology and developed a system identification method using data of different time scales by recovering signals of missing time points. We measured phosphorylation of ERK and CREB, immediate early gene expression products, and mRNAs of decoder genes for neurite elongation in PC12 cell differentiation and performed system identification, revealing the input?output relationships between signaling and gene expression with sensitivity such as graded or switch-like response and with time delay and gain, representing signal transfer efficiency. We predicted and validated the identified system using pharmacological perturbation. Thus, we provide a versatile method for system identification using data with different time scales. | |||||
| 言語 | en | |||||
| 書誌情報 |
en : PLOS Computational Biology 巻 13, 号 12, 発行日 2017-12-27 |
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| artnum | ||||||
| 値 | e1005913 | |||||
| 出版者 | ||||||
| 出版者 | Public Library of Science | |||||
| 言語 | en | |||||
| 出版者版DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1371/journal.pcbi.1005913 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | c 2017 Tsuchiya et al. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
