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Shootin1b Mediates a Mechanical Clutch to Produce Force for Neuronal Migration
http://hdl.handle.net/10061/12602
http://hdl.handle.net/10061/12602caf3ec1f-b801-4d12-9f12-e651522210cf
名前 / ファイル | ライセンス | アクション |
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Press release (413.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-10-18 | |||||
タイトル | ||||||
タイトル | Shootin1b Mediates a Mechanical Clutch to Produce Force for Neuronal Migration | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | neuronal migration | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | olfactory bulb | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | interneuron | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | leading process | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | growth cone | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | shootin1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | L1-CAM | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | clutch molecule | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
著者 |
Minegishi, Takunori
× Minegishi, Takunori× Uesugi, Yasuyuki× Kaneko, Naoko× Yoshida, Wataru× Sawamoto, Kazunobu× Inagaki, Naoyuki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | As an essential step for brain morphogenesis, neurons migrate via mechanical interactions with components of their environment such as neighboring cells and the extracellular matrix. However, the molecular mechanism by which neurons exert forces on their environment during migration remains poorly understood. Here, we show that shootin1b is expressed in migrating mouse olfactory interneurons and accumulates at their leading process growth cone. We demonstrate that shootin1b, by binding to cortactin and L1-CAM, couples F-actin retrograde flow and the adhesive substrate as a clutch molecule. Shootin1b-mediated clutch coupling at the growth cone generates traction force on the substrate, thereby promoting leading process extension and subsequent somal translocation of olfactory interneurons. Furthermore, loss of shootin1 causes abnormal positioning of the interneurons and dysgenesis of the olfactory bulb. Our findings indicate that shootin1b plays a key role in force-driven leading process extension, which propels the migration of olfactory interneurons during olfactory bulb formation. | |||||
書誌情報 |
en : Cell Reports 巻 25, 号 3, p. 624-639.e6, 発行日 2018-10-16 |
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出版者 | ||||||
出版者 | Elsevier | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2211-1247 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1016/j.celrep.2018.09.068 | |||||
権利 | ||||||
権利情報 | c 2018 The Authors. | |||||
著者版フラグ | ||||||
出版タイプ | VoR |