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Arabidopsis R1R2R3-Myb proteins are essential for inhibiting cell division in response to DNA damage
http://hdl.handle.net/10061/12136
http://hdl.handle.net/10061/121362dc14b87-1e7d-4e63-bb9c-ae4c5ac80dd3
| 名前 / ファイル | ライセンス | アクション |
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Press release (528.0 kB)
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fulltext (2.7 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-09-26 | |||||
| タイトル | ||||||
| タイトル | Arabidopsis R1R2R3-Myb proteins are essential for inhibiting cell division in response to DNA damage | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| 著者 |
Chen, Poyu
× Chen, Poyu× Takatsuka, Hirotomo× Takahashi, Naoki× Kurata, Rie× Fukao, Yoichiro× Kobayashi, Kosuke× Ito, Masaki× Umeda, Masaaki |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Inhibition of cell division is an active response to DNA damage that enables cells to maintain genome integrity. However, how DNA damage arrests the plant cell cycle is largely unknown. Here, we show that the repressor-type R1R2R3-Myb transcription factors (Rep-MYBs), which suppress G2/M-specific genes, are required to inhibit cell division in response to DNA damage. Knockout mutants are resistant to agents that cause DNA double-strand breaks and replication stress. Cyclin-dependent kinases (CDKs) can phosphorylate Rep-MYBs in vitro and are involved in their proteasomal degradation. DNA damage reduces CDK activities and causes accumulation of Rep-MYBs and cytological changes consistent with cell cycle arrest. Our results suggest that CDK suppressors such as CDK inhibitors are not sufficient to arrest the cell cycle in response to DNA damage but that Rep-MYB-dependent repression of G2/M-specific genes is crucial, indicating an essential function for Rep-MYBs in the DNA damage response. | |||||
| 書誌情報 |
en : Nature Communications 巻 8, 号 1, 発行日 2017-09-21 |
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| artnum | ||||||
| 値 | 635 | |||||
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| 出版者 | Springer Nature | |||||
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| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2041-1723 | |||||
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| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 28935922 | |||||
| 出版者版DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1038/s41467-017-00676-4 | |||||
| 収録物識別子 | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA12645905 | |||||
| 権利 | ||||||
| 権利情報 | c The Author(s) 2017 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
