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Structural mechanisms of human RecQ helicases WRN and BLM
http://hdl.handle.net/10061/10984
http://hdl.handle.net/10061/1098404dd1e1e-97c0-4bd8-b2d7-09a9442acd40
名前 / ファイル | ライセンス | アクション |
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fulltext (5.7 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2016-08-31 | |||||
タイトル | ||||||
タイトル | Structural mechanisms of human RecQ helicases WRN and BLM | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Werner syndrome | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Bloom syndrome | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | WRN | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | BLM | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | DNA helicase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Holliday junction | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | structural biology | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
著者 |
Kitano, Ken
× Kitano, Ken |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The RecQ family DNA helicases WRN (Werner syndrome protein) and BLM (Bloom syndrome protein) play a key role in protecting the genome against deleterious changes. In humans, mutations in these proteins lead to rare genetic diseases associated with cancer predisposition and accelerated aging. WRN and BLM are distinguished from other helicases by possessing signature tandem domains toward the C terminus, referred to as the RecQ C-terminal (RQC) and helicase-and-ribonuclease D-C-terminal (HRDC) domains. Although the precise function of the HRDC domain remains unclear, the previous crystal structure of a WRN RQC-DNA complex visualized a central role for the RQC domain in recognizing, binding and unwinding DNA at branch points. In particular, a prominent hairpin structure (the β-wing) within the RQC winged-helix motif acts as a scalpel to induce the unpairing of a Watson-Crick base pair at the DNA duplex terminus. A similar RQC-DNA interaction was also observed in the recent crystal structure of a BLM-DNA complex. I review the latest structures of WRN and BLM, and then provide a docking simulation of BLM with a Holliday junction. The model offers an explanation for the efficient branch migration activity of the RecQ family toward recombination and repair intermediates. | |||||
書誌情報 |
en : Frontiers in Genetics 巻 5, p. 366, 発行日 2014-10-29 |
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出版者 | ||||||
出版者 | Frontiers Media | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1664-8021 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 25400656 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.3389/fgene.2014.00366 | |||||
権利 | ||||||
権利情報 | c 2014 Kitano. | |||||
著者版フラグ | ||||||
出版タイプ | VoR |