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Shootin1-cortactin interaction mediates signal-force transduction for axon outgrowth
http://hdl.handle.net/10061/10086
http://hdl.handle.net/10061/100864cae5590-3221-41b4-b328-1cb390f6e74e
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2015-08-20 | |||||
タイトル | ||||||
タイトル | Shootin1-cortactin interaction mediates signal-force transduction for axon outgrowth | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
著者 |
Kubo, Yusuke
× Kubo, Yusuke× Baba, Kentarou× Toriyama, Michinori× Minegishi, Takunori× Sugiura, Tadao× Kozawa, Satoshi× Ikeda, Kazushi× Inagaki, Naoyuki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Motile cells transduce environmental chemical signals into mechanical forces to achieve properly controlled migration. This signal-force transduction is thought to require regulated mechanical coupling between actin filaments (F-actins), which undergo retrograde flow at the cellular leading edge, and cell adhesions via linker "clutch" molecules. However, the molecular machinery mediating this regulatory coupling remains unclear. Here we show that the F-actin binding molecule cortactin directly interacts with a clutch molecule, shootin1, in axonal growth cones, thereby mediating the linkage between F-actin retrograde flow and cell adhesions through L1-CAM. Shootin1-cortactin interaction was enhanced by shootin1 phosphorylation by Pak1, which is activated by the axonal chemoattractant netrin-1. We provide evidence that shootin1-cortactin interaction participates in netrin-1-induced F-actin adhesion coupling and in the promotion of traction forces for axon outgrowth. Under cell signaling, this regulatory F-actin adhesion coupling in growth cones cooperates with actin polymerization for efficient cellular motility. | |||||
書誌情報 |
en : The Journal of Cell Biology 巻 210, 号 4, p. 663-676, 発行日 2015-08-17 |
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出版者 | ||||||
出版者 | The Rockefeller University Press | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1540-8140 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1083/jcb.201505011 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00694812 | |||||
権利 | ||||||
権利情報 | c 2015 Kubo et al. | |||||
著者版フラグ | ||||||
出版タイプ | VoR |