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Cytokinins Control Endocycle Onset by Promoting the Expression of an APC/C Activator in Arabidopsis Roots
http://hdl.handle.net/10061/9172
http://hdl.handle.net/10061/917237f9423a-b4f7-42dc-b855-d76ef04fea78
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-09-18 | |||||
タイトル | ||||||
タイトル | Cytokinins Control Endocycle Onset by Promoting the Expression of an APC/C Activator in Arabidopsis Roots | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
著者 |
Takahashi, Naoki
× Takahashi, Naoki× Kajihara, Takehiro× Okamura, Chieko× Kim, Yoonhee× Katagiri, Youhei× Okushima, Yoko× Matsunaga, Sachihiro× Hwang, Ildoo× Umeda, Masaaki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Plant roots respond to various internal and external signals and adjust themselves to changes of environmental conditions. In the root meristem, stem cells produce daughter cells that continue to divide several times. When these latter cells reach the transition zone, they stop dividing and enter the endocycle, a modified cell cycle in which DNA replication is repeated without mitosis or cytokinesis. The resultant DNA polyploidization, named endoreduplication, is usually associated with an increase of nuclear and cell volume and with cell differentiation [1,2,3,4]. At the transition zone, cytokinin signaling activates two transcription factors, type-B ARABIDOPSIS RESPONSE REGULATOR 1 (ARR1) and ARR12, and induces SHY2/IAA3, a member of the Aux/IAA family of auxin signaling repressors. This inhibits auxin signaling and reduces the expression of auxin efflux carriers, resulting in cell division arrest [5]. Such counteracting actions of two hormones are assumed to determine meristem size. However, it remains unknown whether cytokinins additionally control meristem size through an auxin-independent pathway. Here we show that, in Arabidopsis, the cytokinin-activated ARR2 directly upregulates the expression of CCS52A1, which encodes an activator of an E3 ubiquitin ligase, anaphase-promoting complex/cyclosome (APC/C) [6], thereby promoting the onset of the endocycle and restricting meristem size. Our genetic data revealed that CCS52A1 function is independent of SHY2-mediated control of auxin signaling, indicating that downregulation of auxin signaling and APC/C-mediated degradation of cell-cycle regulators cooperatively promote endocycle onset, and thus fine tune root growth. | |||||
書誌情報 |
en : Current Biology 巻 23, 号 18, p. 1812-1817, 発行日 2013-09-12 |
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出版者 | ||||||
出版者 | Elsevier | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0960-9822 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1016/j.cub.2013.07.051 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA1081652X | |||||
権利 | ||||||
権利情報 | c 2013 Elsevier | |||||
著者版フラグ | ||||||
出版タイプ | AM |