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Astrocyte-Specific Genes Are Generally Demethylated in Neural Precursor Cells Prior to Astrocytic Differentiation
http://hdl.handle.net/10061/8565
http://hdl.handle.net/10061/856531c72b9b-6830-476e-837a-38eabdddb09b
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2012-10-03 | |||||
タイトル | ||||||
タイトル | Astrocyte-Specific Genes Are Generally Demethylated in Neural Precursor Cells Prior to Astrocytic Differentiation | |||||
言語 | ||||||
言語 | eng | |||||
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資源タイプ | journal article | |||||
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アクセス権 | open access | |||||
著者 |
Hatada, Izuho
× Hatada, Izuho× Namihira, Masakazu× Morita, Sumiyo× Kimura, Mika× Horii, Takuro× Nakashima, Kinichi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Epigenetic changes are thought to lead to alterations in the property of cells, such as differentiation potential. Neural precursor cells (NPCs) differentiate only into neurons in the midgestational brain, yet they become able to generate astrocytes in the late stage of development. This differentiation-potential switch could be explained by epigenetic changes, since the promoters of astrocyte-specific marker genes, glial fibrillary acidic protein (Gfap) and S100b, have been shown to become demethylated in late-stage NPCs prior to the onset of astrocyte differentiation; however, whether demethylation occurs generally in other astrocyctic genes remains unknown. Here we analyzed DNA methylation changes in mouse NPCs between the mid-(E11.5) and late (E14.5) stage of development by a genome-wide DNA methylation profiling method using microarrays and found that many astrocytic genes are demethylated in late-stage NPCs, enabling the cell to become competent to express these genes. Although these genes are already demethylated in late-stage NPCs, they are not expressed until cells differentiate into astrocytes. Thus, late-stage NPCs have epigenetic potential which can be realized in their expression after astrocyte differentiation. | |||||
書誌情報 |
en : PLOS ONE 巻 3, 号 9, 発行日 2008-09-11 |
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e3189 | ||||||
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出版者 | Public Library of Science | |||||
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収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1932-6203 | |||||
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関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1371/journal.pone.0003189 | |||||
権利 | ||||||
権利情報 | Copyright (C) 2008 Public Library of Science. | |||||
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出版タイプ | VoR |