WEKO3
アイテム
{"_buckets": {"deposit": "eb4820b8-880c-4c58-816a-0fb114cbaf05"}, "_deposit": {"created_by": 4, "id": "4037", "owners": [4], "pid": {"revision_id": 0, "type": "depid", "value": "4037"}, "status": "published"}, "_oai": {"id": "oai:naist.repo.nii.ac.jp:00004037", "sets": ["35"]}, "author_link": ["7820", "182", "7821", "7822", "7823", "7824", "89"], "item_7_biblio_info_9": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2017-10-05", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "10", "bibliographicVolumeNumber": "13", "bibliographic_titles": [{"bibliographic_title": "PLOS Computational Biology", "bibliographic_titleLang": "en"}]}]}, "item_7_description_7": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Experiments with drug-induced epilepsy in rat brains and epileptic human brain region reveal that focal cooling can suppress epileptic discharges without affecting the brain’s normal neurological function. Findings suggest a viable treatment for intractable epilepsy cases via an implantable cooling device. However, precise mechanisms by which cooling suppresses epileptic discharges are still not clearly understood. Cooling experiments in vitro presented evidence of reduction in neurotransmitter release from presynaptic terminals and loss of dendritic spines at post-synaptic terminals offering a possible synaptic mechanism. We show that termination of epileptic discharges is possible by introducing a homogeneous temperature factor in a neural mass model which attenuates the post-synaptic impulse responses of the neuronal populations. This result however may be expected since such attenuation leads to reduced post-synaptic potential and when the effect on inhibitory interneurons is less than on excitatory interneurons, frequency of firing of pyramidal cells is consequently reduced. While this is observed in cooling experiments in vitro, experiments in vivo exhibit persistent discharges during cooling but suppressed in magnitude. This leads us to conjecture that reduction in the frequency of discharges may be compensated through intrinsic excitability mechanisms. Such compensatory mechanism is modelled using a reciprocal temperature factor in the firing response function in the neural mass model. We demonstrate that the complete model can reproduce attenuation of both magnitude and frequency of epileptic discharges during cooling. The compensatory mechanism suggests that cooling lowers the average and the variance of the distribution of threshold potential of firing across the population. Bifurcation study with respect to the temperature parameters of the model reveals how heterogeneous response of epileptic discharges to cooling (termination or suppression only) is exhibited. Possibility of differential temperature effects on post-synaptic potential generation of different populations is also explored.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_7_publisher_10": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Public Library of Science", "subitem_publisher_language": "en"}]}, "item_7_relation_15": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "28981509", "subitem_relation_type_select": "PMID"}}]}, "item_7_relation_17": {"attribute_name": "出版者版DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1371/journal.pcbi.1005736", "subitem_relation_type_select": "DOI"}}]}, "item_7_rights_18": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "c 2017 Soriano et al.", "subitem_rights_language": "en"}]}, "item_7_source_id_12": {"attribute_name": "EISSN/PISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1553-7358", "subitem_source_identifier_type": "ISSN"}]}, "item_7_source_id_14": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA12073481", "subitem_source_identifier_type": "NCID"}]}, "item_7_text_25": {"attribute_name": "NAIST ID", "attribute_value_mlt": [{"subitem_text_value": "82040551"}, {"subitem_text_value": "73292872"}]}, "item_7_version_type_20": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Soriano, Jaymar", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "7820", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kubo, Takatomi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "182", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "20631550", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=20631550"}]}, {"creatorNames": [{"creatorName": "Inoue, Takao", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "7821", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kida, Hiroyuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "7822", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamakawa, Toshitaka", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "7823", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suzuki, Michiyasu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "7824", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ikeda, Kazushi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "89", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "10262552", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=10262552"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2023-03-02"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "journal.pcbi.1005736.pdf", "filesize": [{"value": "20.6 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 20600000.0, "url": {"label": "fulltext", "objectType": "fulltext", "url": "https://naist.repo.nii.ac.jp/record/4037/files/journal.pcbi.1005736.pdf"}, "version_id": "18979286-e591-4bc7-b107-c3f37ad9416b"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2023-03-02"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "プレスリリース information_kubo20171004.pdf", "filesize": [{"value": "406.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 406000.0, "url": {"label": "Press Release", "objectType": "other", "url": "https://naist.repo.nii.ac.jp/record/4037/files/プレスリリース information_kubo20171004.pdf"}, "version_id": "100fd0d6-3681-4059-afe4-cef620440ba1"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Differential temperature sensitivity of synaptic and firing processes in a neural mass model of epileptic discharges explains heterogeneous response of experimental epilepsy to focal brain cooling", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Differential temperature sensitivity of synaptic and firing processes in a neural mass model of epileptic discharges explains heterogeneous response of experimental epilepsy to focal brain cooling", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "4", "path": ["35"], "permalink_uri": "http://hdl.handle.net/10061/12138", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2017-10-17"}, "publish_date": "2017-10-17", "publish_status": "0", "recid": "4037", "relation": {}, "relation_version_is_last": true, "title": ["Differential temperature sensitivity of synaptic and firing processes in a neural mass model of epileptic discharges explains heterogeneous response of experimental epilepsy to focal brain cooling"], "weko_shared_id": -1}
Differential temperature sensitivity of synaptic and firing processes in a neural mass model of epileptic discharges explains heterogeneous response of experimental epilepsy to focal brain cooling
http://hdl.handle.net/10061/12138
http://hdl.handle.net/10061/1213801f007d2-1c94-4936-a6ab-0d5951ae92bf
名前 / ファイル | ライセンス | アクション |
---|---|---|
fulltext (20.6 MB)
|
|
|
Press Release (406.0 kB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2017-10-17 | |||||
タイトル | ||||||
タイトル | Differential temperature sensitivity of synaptic and firing processes in a neural mass model of epileptic discharges explains heterogeneous response of experimental epilepsy to focal brain cooling | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
著者 |
Soriano, Jaymar
× Soriano, Jaymar× Kubo, Takatomi× Inoue, Takao× Kida, Hiroyuki× Yamakawa, Toshitaka× Suzuki, Michiyasu× Ikeda, Kazushi |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Experiments with drug-induced epilepsy in rat brains and epileptic human brain region reveal that focal cooling can suppress epileptic discharges without affecting the brain’s normal neurological function. Findings suggest a viable treatment for intractable epilepsy cases via an implantable cooling device. However, precise mechanisms by which cooling suppresses epileptic discharges are still not clearly understood. Cooling experiments in vitro presented evidence of reduction in neurotransmitter release from presynaptic terminals and loss of dendritic spines at post-synaptic terminals offering a possible synaptic mechanism. We show that termination of epileptic discharges is possible by introducing a homogeneous temperature factor in a neural mass model which attenuates the post-synaptic impulse responses of the neuronal populations. This result however may be expected since such attenuation leads to reduced post-synaptic potential and when the effect on inhibitory interneurons is less than on excitatory interneurons, frequency of firing of pyramidal cells is consequently reduced. While this is observed in cooling experiments in vitro, experiments in vivo exhibit persistent discharges during cooling but suppressed in magnitude. This leads us to conjecture that reduction in the frequency of discharges may be compensated through intrinsic excitability mechanisms. Such compensatory mechanism is modelled using a reciprocal temperature factor in the firing response function in the neural mass model. We demonstrate that the complete model can reproduce attenuation of both magnitude and frequency of epileptic discharges during cooling. The compensatory mechanism suggests that cooling lowers the average and the variance of the distribution of threshold potential of firing across the population. Bifurcation study with respect to the temperature parameters of the model reveals how heterogeneous response of epileptic discharges to cooling (termination or suppression only) is exhibited. Possibility of differential temperature effects on post-synaptic potential generation of different populations is also explored. | |||||
書誌情報 |
en : PLOS Computational Biology 巻 13, 号 10, 発行日 2017-10-05 |
|||||
出版者 | ||||||
出版者 | Public Library of Science | |||||
EISSN/PISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1553-7358 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 28981509 | |||||
出版者版DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1371/journal.pcbi.1005736 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12073481 | |||||
権利 | ||||||
権利情報 | c 2017 Soriano et al. | |||||
著者版フラグ | ||||||
出版タイプ | VoR |