WEKO3
アイテム
Tripartite suppression of fission yeast TORC1 signaling by the GATOR1-Sea3 complex, the TSC complex, and Gcn2 kinase
http://hdl.handle.net/10061/14247
http://hdl.handle.net/10061/142473f45897c-80e6-4c4e-9a7e-ec9dcbd456ab
| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-04-19 | |||||
| タイトル | ||||||
| タイトル | Tripartite suppression of fission yeast TORC1 signaling by the GATOR1-Sea3 complex, the TSC complex, and Gcn2 kinase | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Autophagy | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | GATOR1 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | GATOR2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Gcn2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Rag GTPase | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | S. pombe | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | TORC1 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cell biology | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| 著者 |
Tomoyuki, Fukuda
× Tomoyuki, Fukuda× Fajar, Sofyantoro× Yen, Teng Tai× Kim, Hou Chia× Takato, Matsuda× Takaaki, Murase× Yuichi, Morozumi× Hisashi, Tatebe× Tomotake, Kanki× Kazuhiro, Shiozaki |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Mammalian target of rapamycin complex 1 (TORC1) is controlled by the GATOR complex composed of the GATOR1 subcomplex and its inhibitor, the GATOR2 subcomplex, sensitive to amino acid starvation. Previously, we identified fission yeast GATOR1 that prevents deregulated activation of TORC1 (Chia et al., 2017). Here, we report identification and characterization of GATOR2 in fission yeast. Unexpectedly, the GATOR2 subunit Sea3, an ortholog of mammalian WDR59, is physically and functionally proximal to GATOR1, rather than GATOR2, attenuating TORC1 activity. The fission yeast GATOR complex is dispensable for TORC1 regulation in response to amino acid starvation, which instead activates the Gcn2 pathway to inhibit TORC1 and induce autophagy. On the other hand, nitrogen starvation suppresses TORC1 through the combined actions of the GATOR1-Sea3 complex, the Gcn2 pathway, and the TSC complex, another conserved TORC1 inhibitor. Thus, multiple, parallel signaling pathways implement negative regulation of TORC1 to ensure proper cellular starvation responses. | |||||
| 書誌情報 |
en : eLife 巻 10, 発行日 2021-02-03 |
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| artnum | ||||||
| 値 | e60969 | |||||
| 出版者 | ||||||
| 出版者 | eLife Sciences Publications, Ltd | |||||
| ISSN | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 2050-084X | |||||
| PubMed番号 | ||||||
| 関連タイプ | isReplacedBy | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 33534698 | |||||
| 出版者版DOI | ||||||
| 関連タイプ | isReplacedBy | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.7554/eLife.60969 | |||||
| 出版者版URI | ||||||
| 関連タイプ | isReplacedBy | |||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://elifesciences.org/articles/60969 | |||||
| 権利 | ||||||
| 権利情報 | c 2021, Fukuda et al.This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | NA | |||||
