{"created":"2023-07-25T10:29:59.634673+00:00","id":9173,"links":{},"metadata":{"_buckets":{"deposit":"6fe6517c-4cac-4c8b-8c6e-5173b828c34f"},"_deposit":{"created_by":4,"id":"9173","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"9173"},"status":"published"},"_oai":{"id":"oai:naist.repo.nii.ac.jp:00009173","sets":["43:44"]},"author_link":["86","24066","24067","24068","187"],"item_7_biblio_info_9":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-05-22","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{"bibliographic_title":"The EMBO Journal","bibliographic_titleLang":"en"}]}]},"item_7_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Alveolar macrophages (AMs) are specialized tissue‐resident macrophages that orchestrate the immune responses to inhaled pathogens and maintain organ homeostasis of the lung. Dysregulation of AMs is associated with allergic inflammation and asthma. Here, we examined the role of a phosphoinositide kinase PIKfyve in AM development and function. Mice with conditionally deleted PIKfyve in macrophages have altered AM populations. PIKfyve deficiency results in a loss of AKT activation in response to GM‐CSF, a cytokine critical for AM development. Upon exposure to house dust mite extract, mutant mice display severe lung inflammation and allergic asthma accompanied by infiltration of eosinophils and lymphoid cells. Moreover, they have defects in production of retinoic acid and fail to support incorporation of Foxp3+ Treg cells in the lung, resulting in exacerbation of lung inflammation. Thus, PIKfyve plays a role in preventing excessive lung inflammation through regulating AM function.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_7_publisher_10":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"EMBO Press","subitem_publisher_language":"en"}]},"item_7_relation_15":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"28533230","subitem_relation_type_select":"PMID"}}]},"item_7_relation_17":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.15252/embj.201695528","subitem_relation_type_select":"DOI"}}]},"item_7_rights_18":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2017 The Authors","subitem_rights_language":"en"},{"subitem_rights":"出版者許諾条件により、本文は2017年11月22日以降に公開。","subitem_rights_language":"ja"}]},"item_7_source_id_12":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1460-2075","subitem_source_identifier_type":"ISSN"}]},"item_7_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kawasaki, Takumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"86","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60584414","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60584414"}]},{"creatorNames":[{"creatorName":"Ito, Kosuke","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"24066","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miyata, Haruhiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"24067","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Akira, Shizuo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"24068","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawai, Taro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"187","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50456935","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50456935"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-06"}],"displaytype":"detail","filename":"20170405alveolar mac and PIKfyveedit　for embo revice5.pdf","filesize":[{"value":"657.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"fulltext","objectType":"fulltext","url":"https://naist.repo.nii.ac.jp/record/9173/files/20170405alveolar mac and PIKfyveedit　for embo 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kinase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"macrophage development","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Deletion of PIKfyve alters alveolar macrophage populations and exacerbates allergic inflammation in mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Deletion of PIKfyve alters alveolar macrophage populations and exacerbates allergic inflammation in mice","subitem_title_language":"en"}]},"item_type_id":"7","owner":"4","path":["44"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-11-22"},"publish_date":"2017-11-22","publish_status":"0","recid":"9173","relation_version_is_last":true,"title":["Deletion of PIKfyve alters alveolar macrophage populations and exacerbates allergic inflammation in mice"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-11-21T07:32:47.775125+00:00"}