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A diffusion-based neurite length-sensing mechanism involved in neuronal symmetry breaking
http://hdl.handle.net/10061/10670
http://hdl.handle.net/10061/106709801c2dc-58a2-41da-b79a-9a246b385d5d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
fulltext (6.3 MB)
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| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2016-07-27 | |||||
| タイトル | ||||||
| タイトル | A diffusion-based neurite length-sensing mechanism involved in neuronal symmetry breaking | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | feedback loop | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | neuronal polarity | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | quantitative modeling | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | shootin1 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | stochasticity | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| 著者 |
Toriyama, Michinori
× Toriyama, Michinori× Sakumura, Yuichi× Shimada, Tadayuki× Ishii, Shin× Inagaki, Naoyuki |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Although there has been significant progress in understanding the molecular signals that change cell morphology, mechanisms that cells use to monitor their size and length to regulate their morphology remain elusive. Previous studies suggest that polarizing cultured hippocampal neurons can sense neurite length, identify the longest neurite, and induce its subsequent outgrowth for axonogenesis. We observed that shootin1, a key regulator of axon outgrowth and neuronal polarization, accumulates in neurite tips in a neurite length-dependent manner; here, the property of cell length is translated into shootin1 signals. Quantitative live cell imaging combined with modeling analyses revealed that intraneuritic anterograde transport and retrograde diffusion of shootin1 account for its neurite length-dependent accumulation. Our quantitative model further explains that the length-dependent shootin1 accumulation, together with shootin1-dependent neurite outgrowth, constitutes a positive feedback loop that amplifies stochastic fluctuations of shootin1 signals, thereby generating an asymmetric signal for axon specification and neuronal symmetry breaking. | |||||
| 書誌情報 |
en : Molecular Systems Biology 巻 6, 号 1, 発行日 2010-07-27 |
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| 出版者 | ||||||
| 出版者 | John Wiley & Sons, Ltd | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1744-4292 | |||||
| PubMed番号 | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 20664640 | |||||
| 出版者版DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1038/msb.2010.51 | |||||
| 権利 | ||||||
| 権利情報 | Copyright c 1999-2016 John Wiley & Sons, Inc. All Rights Reserved. | |||||
| 権利 | ||||||
| 権利情報 | This is the accepted version of the following article: FULL CITE, which has been published in final form at [http://dx.doi.org/10.1038/msb.2010.51]. This article may be used for non-commercial purposes in accordance with the Wiley Self-Archiving Policy [http://olabout.wiley.com/WileyCDA/Section/id-828039.html]. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
