{"created":"2023-07-25T10:29:57.677926+00:00","id":9130,"links":{},"metadata":{"_buckets":{"deposit":"ad5a33e6-9c81-481d-af10-e009440f150a"},"_deposit":{"created_by":4,"id":"9130","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"9130"},"status":"published"},"_oai":{"id":"oai:naist.repo.nii.ac.jp:00009130","sets":["43:44"]},"author_link":["23462","23463","23464","23465","23466","23467","23468","23469","23470","23471","23472","23473","23474","23475","23476","23477","23478","23479","23480","23481","310"],"item_7_biblio_info_9":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-07-04","bibliographicIssueDateType":"Issued"},"bibliographicVolumeNumber":"1","bibliographic_titles":[{"bibliographic_title":"Nature Microbiology","bibliographic_titleLang":"en"}]}]},"item_7_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Immunoglobulin A (IgA) is the main antibody isotype secreted into the intestinal lumen. IgA plays a critical role in the defence against pathogens and in the maintenance of intestinal homeostasis. However, how secreted IgA regulates gut microbiota is not completely understood. In this study, we isolated monoclonal IgA antibodies from the small intestine of healthy mouse. As a candidate for an efficient gut microbiota modulator, we selected a W27 IgA, which binds to multiple bacteria, but not beneficial ones such as Lactobacillus casei. W27 could suppress the cell growth of Escherichia coli but not L. casei in vitro, indicating an ability to improve the intestinal environment. Indeed W27 oral treatment could modulate gut microbiota composition and have a therapeutic effect on both lymphoproliferative disease and colitis models in mice. Thus, W27 IgA oral treatment is a potential remedy for inflammatory bowel disease, acting through restoration of host?microbial symbiosis.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_7_publisher_10":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Macmillan Publishers Limited","subitem_publisher_language":"en"}]},"item_7_relation_17":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1038/nmicrobiol.2016.103","subitem_relation_type_select":"DOI"}}]},"item_7_rights_18":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2016 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.; 出版者許諾条件により本文は2017年1月4日以降公開。","subitem_rights_language":"en"}]},"item_7_source_id_12":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2058-5276","subitem_source_identifier_type":"ISSN"}]},"item_7_text_26":{"attribute_name":"artnum","attribute_value_mlt":[{"subitem_text_value":"16103"}]},"item_7_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Okai, Shinsaku","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"23462","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Usui, Fumihito","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"23463","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yokota, Shuhei","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"23464","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hori-i, Yusaku","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"23465","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hasegawa, Makoto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"23466","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakamura, Toshinobu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"23467","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kurosawa, Manabu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"23468","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okada, Seiji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"23469","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamamoto, Kazuya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"23470","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishiyama, Eri","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"23471","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mori, Hiroshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"23472","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamada, Takuji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"23473","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kurokawa, Ken","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"23474","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsumoto, Satoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"23475","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nanno, Masanobu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"23476","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Naito, Tomoaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"23477","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Watanabe, Yohei","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"23478","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kato, Tamotsu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"23479","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miyauchi, Eiji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"23480","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohno, Hiroshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"23481","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shinkura, Reiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"310","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50362471","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50362471"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-06"}],"displaytype":"detail","filename":"Okai et al. 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