@article{oai:naist.repo.nii.ac.jp:00009130,
 author = {Okai, Shinsaku and Usui, Fumihito and Yokota, Shuhei and Hori-i, Yusaku and Hasegawa, Makoto and Nakamura, Toshinobu and Kurosawa, Manabu and Okada, Seiji and Yamamoto, Kazuya and Nishiyama, Eri and Mori, Hiroshi and Yamada, Takuji and Kurokawa, Ken and Matsumoto, Satoshi and Nanno, Masanobu and Naito, Tomoaki and Watanabe, Yohei and Kato, Tamotsu and Miyauchi, Eiji and Ohno, Hiroshi and Shinkura, Reiko},
 journal = {Nature Microbiology},
 month = {Jul},
 note = {Immunoglobulin A (IgA) is the main antibody isotype secreted into the intestinal lumen. IgA plays a critical role in the defence against pathogens and in the maintenance of intestinal homeostasis. However, how secreted IgA regulates gut microbiota is not completely understood. In this study, we isolated monoclonal IgA antibodies from the small intestine of healthy mouse. As a candidate for an efficient gut microbiota modulator, we selected a W27 IgA, which binds to multiple bacteria, but not beneficial ones such as Lactobacillus casei. W27 could suppress the cell growth of Escherichia coli but not L. casei in vitro, indicating an ability to improve the intestinal environment. Indeed W27 oral treatment could modulate gut microbiota composition and have a therapeutic effect on both lymphoproliferative disease and colitis models in mice. Thus, W27 IgA oral treatment is a potential remedy for inflammatory bowel disease, acting through restoration of host?microbial symbiosis.},
 title = {High-affinity monoclonal IgA regulates gut microbiota and prevents colitis in mice},
 volume = {1},
 year = {2016}
}