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アイテム
Developmental requirement of gp130 signaling in neuronal survival and astrocyte differentiation.
http://hdl.handle.net/10061/8558
http://hdl.handle.net/10061/85581d51bf36-a504-48c5-aaf5-d69a931f5c2e
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
fulltext (470.8 kB)
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| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2012-10-03 | |||||
| タイトル | ||||||
| タイトル | Developmental requirement of gp130 signaling in neuronal survival and astrocyte differentiation. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | gp130 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | deficient mice | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cytokine | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | astrocyte | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | motor neuron | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | sensory neuron | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| 著者 |
Nakashima, Kinichi
× Nakashima, Kinichi× Wiese, Stefan× Yanagisawa, Makoto× Arakawa, Hirokazu× Kimura, Naoki× Hisatsune, Tatsuhiro× Yoshida, Kanji× Kishimoto, Tadamitsu× Sendtner, Michael× Taga, Tetsuya |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | gp130 is a signal-transducing receptor component used in common by the interleukin-6 (IL-6) family of hematopoietic and neurotrophic cytokines, including IL-6, IL-11, leukemia-inhibitory factor, ciliary neurotrophic factor, oncostatin-M, and cardiotrophin-1. We have examined in this study a role of gp130 in the nervous system by analyzing developmental cell death of several neuronal populations and the differentiation of astrocytes in gp130-deficient mice. A significant reduction was observed in the number of sensory neurons in L5 dorsal root ganglia and motoneurons in the facial nucleus, the nucleus ambiguus, and the lumbar spinal cord in gp130 ?/? mice on embryonic day 18.5. On the other hand, no significant neuronal loss was detectable on day 14.5, suggesting a physiological role of gp130 in supporting newly generated neurons during the late phase of development when naturally occurring cell death takes place. Moreover, expression of an astrocyte marker, GFAP, was severely reduced in the brain of gp130 ?/? mice. Our data demonstrate that gp130 expression is essential for survival of subgroups of differentiated motor and sensory neurons and for the differentiation of major populations of astrocytesin vivo. | |||||
| 書誌情報 |
en : The Journal of Neuroscience 巻 19, 号 13, p. 5429-5434, 発行日 1999-07-01 |
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| 出版者 | ||||||
| 出版者 | Society for Neuroscience | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0270-6474 | |||||
| 出版者版DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1523/JNEUROSCI.19-13-05429.1999 | |||||
| 収録物識別子 | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA10620404 | |||||
| 権利 | ||||||
| 権利情報 | Copyright (C) 1999 Society for Neuroscience. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
