| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2026-03-31 |
| タイトル |
|
|
タイトル |
Chromatin state architecture governs transcription factor accessibility across plant genomes |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
| 著者 |
Shukla, Vikas
Axelsson, Elin
久永, 哲也
Haseloff, Jim
Berger, Frédéric
Romani, Facundo
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The complexity of varied modifications of chromatin composition is integrated in archetypal combinations called chromatin states that predict the local potential for transcription. The degree of conservation of chromatin states has not been established amongst plants, and how they interact with transcription factors is unknown. Here we identify and characterize chromatin states in the flowering plant Arabidopsis thaliana and the bryophyte Marchantia polymorpha, showing a large degree of functional conservation over more than 450 million years of land plant evolution. We used this new resource of conserved plant chromatin states to understand the influence of chromatin states on gene regulation. We established the preferential association of chromatin states with binding sites and activity of transcription factors. These associations define three main groups of transcription factors that bind upstream of the transcription start site, at the + 1 nucleosome or further downstream of the transcription start site and broadly associate with distinct biological functions including a list of potential candidate pioneer factors we know little about in plants, compared to their important roles in animal stem cells and early development. |
| 書誌情報 |
en : PLOS Genetics
巻 22,
号 1,
p. 1-25,
ページ数 25,
発行日 2026-01-22
|
| 出版者 |
|
|
出版者 |
Public Library of Science |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
1553-7404 |
| 出版者版DOI |
|
|
関連タイプ |
isReplacedBy |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1371/journal.pgen.1012015 |
| 出版者版URI |
|
|
関連タイプ |
isReplacedBy |
|
|
識別子タイプ |
URI |
|
|
関連識別子 |
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1012015 |
| 権利 |
|
|
権利情報Resource |
http://creativecommons.org/licenses/by/4.0/ |
|
権利情報 |
© 2026 Shukla et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| 著者版フラグ |
|
|
出版タイプ |
NA |
| 助成情報 |
|
|
|
助成機関名 |
Austrian Science Fund (FWF) |
|
|
研究課題番号 |
P32054 |
| 助成情報 |
|
|
|
助成機関名 |
Austrian Science Fund (FWF) |
|
|
研究課題番号 |
P36231 |
| 助成情報 |
|
|
|
助成機関名 |
Austrian Science Fund (FWF) |
|
|
研究課題番号 |
PAT1104523 |
| 助成情報 |
|
|
|
助成機関名 |
Austrian Science Fund (FWF) |
|
|
研究課題番号 |
PAT6138924 |
| 助成情報 |
|
|
|
助成機関名 |
European Commission |
|
|
研究課題番号 |
847548 |
| 助成情報 |
|
|
|
助成機関名 |
Leverhulme Trust |
|
|
研究課題番号 |
ECF-2023-534 |
| 助成情報 |
|
|
|
助成機関名 |
Isaac Newton Trust |
|
|
研究課題番号 |
23.08(f) |
