| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2026-03-23 |
| タイトル |
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タイトル |
Thiol-ene derivatization of polycarbonates from 5-methylene-1,3-dioxane-2-one: an efficient and practical way to tune the surface biocompatibility of polycarbonate films |
| 言語 |
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言語 |
eng |
| キーワード |
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主題Scheme |
Other |
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主題 |
Biochemistry |
| キーワード |
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主題Scheme |
Other |
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主題 |
Polymers |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
Sarisuta, Kamolchanok
Martín-Vaca, Blanca
Bourissou, Didier
Monot, Julien
Chanthaset, Nalinthip
網代, 広治
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Poly(trimethylene carbonate) (PTMC) is a biodegradable polymer that is widely utilized in biomedical fields because of the soft mechanical properties conferred by its low glass transition temperature. However, its application is limited by the lack of reactive sites on its backbone for chemical modifications. To overcome this limitation, a copolymer, poly(trimethylene carbonate-r-5-methylene-1,3-dioxane-2-one) (PTMC-r-PexTMC), was developed as a platform for postpolymerization functionalization. Using thiol-ene click chemistry, diol and carboxylic acid groups were grafted onto PTMC-r-PexTMC at levels ranging from 1 to 30 mol% to tailor its hydrophilicity and surface compatibility. Thermogravimetric and contact angle analyses revealed that both the thermal stability and hydrophilicity increased with the degree of functionalization. Importantly, copolymers containing 30 mol% diol units inhibited platelet adhesion more effectively than those with equivalent carboxylic acid content did, indicating that both hydrophilicity and surface charge influence biocompatibility. Further studies involving degradation in PBS and doxorubicin release confirmed the potential of these functional groups to modulate polymer performance. These findings highlight the value of surface modification in increasing the biocompatibility of polycarbonates for advanced medical applications. |
| 書誌情報 |
en : Polymer Journal
発行日 2025-07-01
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| 出版者 |
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出版者 |
Springer Nature |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
1349-0540 |
| 出版者版DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1038/s41428-025-01068-y |
| 出版者版URI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
URI |
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関連識別子 |
https://www.nature.com/articles/s41428-025-01068-y |
| 権利 |
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権利情報 |
Copyright © 2025, The Author(s), under exclusive licence to The Society of Polymer Science, Japan. This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1038/s41428-025-01068-y . |
| 著者版フラグ |
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出版タイプ |
AM |
| 助成情報 |
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助成機関名 |
Centre National de la Recherche Scientifique |
| 助成情報 |
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助成機関名 |
Université de Toulouse 3 |
| 助成情報 |
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助成機関名 |
Suzuken Memorial Foundation |
| 助成情報 |
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助成機関名 |
Japan Society for the Promotion of Science (JSPS) |
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研究課題番号 |
JP24K01555 |
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研究課題番号URI |
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K01555/ |
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研究課題名 |
大きな双極子モーメントを持つ分解性高分子と多糖類による複合材料 |
fulltext (1.9 MB)
