| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2026-01-15 |
| タイトル |
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タイトル |
Stem cell regulators drive a G1 duration gradient during plant root development |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
Echevarría, Clara
Desvoyes, Bénédicte
Marconi, Marco
Franco-Zorrilla, José Manuel
Lee, Laura
梅田, 正明
Sablowski, Robert
Birnbaum, Kenneth D
Wabnik, Krzysztof
Gutierrez, Crisanto
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Organogenesis relies on the coordination of cell proliferation with developmental programs. In meristems, where new plant organs initiate, the cell proliferation potential depends on stem cell regulators, but the mechanisms linking their local activity with the cell cycle machinery remain unknown. Here we show a positional gradient of G1 duration in the Arabidopsis root meristem spanning from ~2 h near the meristem boundary to more than 20 h in the early stem cell derivatives. Mutations in the stem cell regulatory PLETHORA (PLT) genes and the cell cycle RETINOBLASTOMA-RELATED 1 gene shortened G1 duration, abolishing the G1 duration gradient, whereas PLT2 overexpression increased G1 duration. Data-driven computer modelling supported the presence of an incoherent feed-forward loop. We found that PLT genes are drivers with simultaneous and opposing roles in maintaining stem cell activity and inhibiting G1 progression through a cascade involving the CDK inhibitor KRP5, a PLT target and RETINOBLASTOMA-RELATED 1. The G1 duration gradient is developmentally regulated and established after the emergence of lateral roots from the primary root and correlates with increased tolerance to genome damage. Our study establishes a previously undescribed proximal–distal G1 duration gradient during root development that is shaped by the balanced activity of stem cell maintenance and cell cycle regulators. |
| 書誌情報 |
en : Nature Plants
巻 11,
号 10,
p. 2145-2155,
ページ数 24,
発行日 2025-09-18
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| 出版者 |
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出版者 |
Springer Nature |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2055-0278 |
| 出版者版DOI |
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関連タイプ |
isReplacedBy |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1038/s41477-025-02109-3 |
| 出版者版URI |
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関連タイプ |
isReplacedBy |
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識別子タイプ |
URI |
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関連識別子 |
https://www.nature.com/articles/s41477-025-02109-3 |
| 権利 |
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権利情報Resource |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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権利情報 |
© The Author(s) 2025.This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/ by-nc-nd/4.0/. |
| 著者版フラグ |
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出版タイプ |
NA |
| 助成情報 |
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助成機関名 |
Spanish Ministry of Science and Innovation |
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研究課題番号 |
RTI2018-094793-B-I00 |
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助成機関名 |
Spanish Ministry of Science and Innovation |
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研究課題番号 |
PID2021-123319NB-I00 |
| 助成情報 |
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助成機関名 |
European Union |
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研究課題番号 |
2018-AdG_833617 |
| 助成情報 |
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助成機関名 |
Spanish Ministry of Science and Innovation |
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研究課題番号 |
PID2024-159682NB-I00 |
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助成機関名 |
Spanish Ministry of Science and Innovation |
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研究課題番号 |
PGC2018-093387-A407 I00 |
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助成機関名 |
Spanish Ministry of Science and Innovation |
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研究課題番号 |
PID2021-122158NB-I00 |
| 助成情報 |
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助成機関名 |
Comunidad de Madrid |
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研究課題番号 |
2021-5A/BIO-20952 |
| 助成情報 |
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助成機関名 |
Spanish Ministry of Science and Innovation |
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研究課題番号 |
SEV-2016-0672 |
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研究課題名 |
Severo Ochoa Programme for Centres of Excellence |
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助成機関名 |
Spanish Ministry of Science and Innovation |
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研究課題番号 |
CEX2020-000999-S |
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研究課題名 |
Severo Ochoa Programme for Centres of Excellence |
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助成機関名 |
Spanish Ministry of Science and Innovation |
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研究課題番号 |
BIO2017-86851-P |
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助成機関名 |
Spanish Ministry of Science and Innovation |
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研究課題番号 |
BIO2020-119451GB-I00 |
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助成機関名 |
National Science Foundation |
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研究課題番号 |
IOS-1934388 |
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助成機関名 |
National Institutes of Health |
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研究課題番号 |
R35GM136362 |
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助成機関名 |
Biotechnology and Biological Sciences Research Council |
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研究課題番号 |
BB/J004588/1 |
| 助成情報 |
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助成機関名 |
Japan Society for the Promotion of Science (JSPS) |
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研究課題番号 |
17H06470 |
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研究課題番号URI |
https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-17H06470/ |
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研究課題名 |
植物の生命力を支える多能性幹細胞の基盤原理 |
| 助成情報 |
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助成機関名 |
Japan Society for the Promotion of Science (JSPS) |
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研究課題番号 |
17H06477 |
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研究課題番号URI |
https://kaken.nii.ac.jp/ja/grant/KAKENHI-PLANNED-17H06477/ |
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研究課題名 |
多能性幹細胞の維持・再生機構の解明 |
| 助成情報 |
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助成機関名 |
Japan Society for the Promotion of Science (JSPS) |
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研究課題番号 |
21H04715 |
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研究課題番号URI |
https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-21H04715/ |
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研究課題名 |
DNA倍加誘導に必要なクロマチン制御系の解明 |
| 助成情報 |
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助成機関名 |
Ramón Areces Foundation |
| 助成情報 |
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助成機関名 |
Banco Santander |
| 助成情報 |
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助成機関名 |
Severo Ochoa Molecular Biology Center |
