| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-12-18 |
| タイトル |
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|
タイトル |
Functional characterization of the Csm1-like protein TITAN 9 in Arabidopsis thaliana |
| 言語 |
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|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
plant genetics |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
plant bioinformatics |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
plant Biology |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
plant physiology |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
plant systematics |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
plant evolution |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
plant development |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
| 著者 |
Zhang, Zhijian
Bower, Franziska
小牧, 伸一郎
Pettko-Szandtner, Aladar
Skuba, Anastasiia O.
Tromer, Eelco C.
Magyar, Zoltan
Heese, Maren
Schnittger, Arp
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Kinetochores are essential for chromosome segregation in eukaryotes. An important component of kinetochores in opisthokonta is Csm1. However, its function appears to be diversified and, while Csm1 in budding yeast is a component of the monopolin complex mediating mono-orientation of sister kinetochores during meiosis I, the fission yeast homolog Pcs1 prevents merotelic spindle microtubule attachments during mitosis and meiosis II. Here, we have characterized TITAN9 (TTN9), a distantly related Csm1-like protein in the flowering plant Arabidopsis. TTN9 accumulates in mitotic and meiotic tissue and localizes to centromeres throughout the cell cycle. By analyzing proteome-wide TTN9 associated proteins, we identified a substantial subset of the Arabidopsis kinetochore proteome, including DSN1, mirroring known Csm1 interactions in yeast. While homozygous ttn9 mutants are not viable, a meiosis-specific knock-down of TTN9 causes chromosome segregation defects and split centromeres during meiosis I. These findings suggest that Csm1-like proteins contribute to conserved kinetochore functions across eukaryotes. |
| 書誌情報 |
en : iScience
巻 28,
号 9,
p. 1-18,
ページ数 18,
発行日 2025-09-19
|
| 出版者 |
|
|
出版者 |
Cell Press |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2589-0042 |
| 出版者版DOI |
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|
関連タイプ |
isReplacedBy |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1016/j.isci.2025.113251 |
| 出版者版URI |
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|
関連タイプ |
isReplacedBy |
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|
識別子タイプ |
URI |
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|
関連識別子 |
https://www.sciencedirect.com/science/article/pii/S2589004225015123 |
| 権利 |
|
|
権利情報Resource |
https://creativecommons.org/licenses/by-nc/4.0/ |
|
権利情報 |
© 2025 The Author(s). Published by Elsevier Inc. 1 This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/). |
| 著者版フラグ |
|
|
出版タイプ |
NA |
| 助成情報 |
|
|
|
助成機関名 |
Deutsche Forschungsgemeinshaft (DFG) |
|
|
研究課題番号 |
SCHN736/21 |
|
|
研究課題名 |
MeioMove |
| 助成情報 |
|
|
|
助成機関名 |
European Commission |
|
|
研究課題番号 |
739593 |
|
|
研究課題名 |
Horizon 2020 |
| 助成情報 |
|
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|
助成機関名 |
NKFIA |
|
|
研究課題番号 |
2022-2.1.1-NL-2022-00005 |
| 助成情報 |
|
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|
助成機関名 |
China Scholarship Council (CSC) |
| 助成情報 |
|
|
|
助成機関名 |
Friedrich-Ebert-Stiftung (FES) |
