| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-11-28 |
| 日付 |
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日付 |
2026-07-04 |
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日付タイプ |
Available |
| タイトル |
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タイトル |
The transcriptional repressors IAA5 and IAA29 participate in DNA damage-induced stem cell death in Arabidopsis roots |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
embargoed access |
| 著者 |
Takahashi, Naoki
Ogita, Nobuo
Koike, Toshiya
Nishimura, Kohei
Inagaki, Soichi
Zhang, Ye
Higaki, Takumi
梅田, 正明
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Plants generate organs continuously during postembryonic development. Thus, their ability to preserve stem cells in changing environments is crucial for their survival. Genotoxic stress threatens genome stability in all somatic cells. However, in the meristem, only the stem cells actively die in response to DNA damage, followed by stem cell replenishment that guarantees genome stability in these cells. Cytokinin biosynthesis-induced inhibition of downward auxin flow participates in DNA damage-induced stem cell death in roots. Without this system, stem cell death occurs at a reduced but significant level, suggesting another mechanism governing the DNA damage response in stem cells. Here, we demonstrate that in response to DNA double-strand breaks, the AUXIN/INDOLE-3-ACETIC ACID (Aux/IAA) family members IAA5 and IAA29, encoding negative regulators of auxin signaling, are induced in Arabidopsis (Arabidopsis thaliana) roots. The transcription factor SUPPRESSOR OF GAMMA RESPONSE 1 directly induces their expression as an active response to DNA damage. In the iaa5 iaa29 double mutant, DNA damage-induced stem cell death is greatly suppressed, while it is fully restored by the expression of a stable form of IAA5 in vascular stem cells. Our genetic data reveal that reduced auxin signaling around the stem cell niche, caused by IAA5 and IAA29 induction and enhanced cytokinin biosynthesis, is a prerequisite for cell death induction, thus playing a central role in maintaining genome integrity in root stem cells. |
| 書誌情報 |
en : Plant Physiology
巻 198,
号 3,
p. 1-13,
ページ数 13,
発行日 2025-07-04
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| 出版者 |
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出版者 |
Oxford University Press |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
1532-2548 |
| 出版者版DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1093/plphys/kiaf303 |
| 出版者版URI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
URI |
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関連識別子 |
https://academic.oup.com/plphys/article/198/3/kiaf303/8185758 |
| 権利 |
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権利情報 |
© The Author(s) 2025. This is a pre-copyedited, author-produced version of an article accepted for publication in Plant Physiology following peer review. The version of record Takahashi Naoki, Ogita Nobuo, Koike Toshiya, Nishimura Kohei, Inagaki Soichi, Zhang Ye, Higaki Takumi, Umeda Masaaki. 2025. The transcriptional repressors IAA5 and IAA29 participate in DNA damage-induced stem cell death in Arabidopsis roots. Plant Physiology. 198, 3, kiaf303. is available online at: https://doi.org/10.1093/plphys/kiaf303 . 出版社許諾条件により、本文は2026年7月4日以降に公開 |
| 著者版フラグ |
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出版タイプ |
AM |
| 助成情報 |
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助成機関名 |
Japan Society for the Promotion of Science (JSPS) |
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研究課題番号 |
17H06477 |
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研究課題番号URI |
https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-17H06477/ |
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研究課題名 |
多能性幹細胞の維持・再生機構の解明 |
| 助成情報 |
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助成機関名 |
Japan Society for the Promotion of Science (JSPS) |
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研究課題番号 |
17H06470 |
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研究課題番号URI |
https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-17H06470/ |
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研究課題名 |
植物の生命力を支える多能性幹細胞の基盤原理 |
| 助成情報 |
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助成機関名 |
Japan Society for the Promotion of Science (JSPS) |
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研究課題番号 |
19K06708 |
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研究課題番号URI |
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K06708/ |
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研究課題名 |
ストレスに応答した植物の細胞周期停止を制御する分子基盤の解明 |
| 助成情報 |
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助成機関名 |
Japan Society for the Promotion of Science (JSPS) |
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研究課題番号 |
21H04715 |
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研究課題番号URI |
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H04715/ |
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研究課題名 |
DNA倍加誘導に必要なクロマチン制御系の解明 |
| 助成情報 |
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助成機関名 |
Japan Society for the Promotion of Science (JSPS) |
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研究課題番号 |
JP22H04926 |
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研究課題番号URI |
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H04926/ |
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研究課題名 |
先端バイオイメージング支援プラットフォーム |
| 助成情報 |
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助成機関名 |
Japan Society for the Promotion of Science (JSPS) |
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研究課題番号 |
22H04722 |
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研究課題番号URI |
https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-22H04722/ |
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研究課題名 |
根の成長を制御する周期と変調の分子基盤の解明 |
| 助成情報 |
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助成機関名 |
Japan Society for the Promotion of Science (JSPS) |
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研究課題番号 |
22K06265 |
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研究課題番号URI |
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K06265/ |
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研究課題名 |
植物の組織再生を支える分子基盤の解明 |
| 助成情報 |
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助成機関名 |
Japan Society for the Promotion of Science (JSPS) |
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研究課題番号 |
22K15143 |
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研究課題番号URI |
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K15143/ |
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研究課題名 |
Study on brassinosteroid-mediated regulation of stem cell regeneration in roots |
| 助成情報 |
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助成機関名 |
The Sumitomo Foundation |
fulltext (16.2 MB)
