| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-11-28 |
| タイトル |
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タイトル |
SUPPRESOR OF GAMMA RESPONSE 1 promotes early onset of endoreplication upon DNA double-strand breaks by inducing CCS52A1 expression in Arabidopsis roots |
| 言語 |
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言語 |
eng |
| キーワード |
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主題Scheme |
Other |
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主題 |
Arabidopsis |
| キーワード |
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主題Scheme |
Other |
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主題 |
CELL CYCLE SWITCH 52 A1 |
| キーワード |
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主題Scheme |
Other |
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主題 |
DNA damage |
| キーワード |
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主題Scheme |
Other |
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主題 |
Endoreplication |
| キーワード |
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主題Scheme |
Other |
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主題 |
Root |
| キーワード |
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主題Scheme |
Other |
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主題 |
SUPPRESSOR OF GAMMA RESPONSE 1 |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
Wada, Toshiki
Sakamoto, Ayako N.
梅田, 正明
Takahashi, Naoki
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Living organisms are constantly at the risk of DNA damage caused by factors such as DNA replication errors, reactive oxygen species, and UV radiation. In plants, DNA damage activates the NAC-type transcription factor SUPPRESSOR OF GAMMA RESPONSE 1 (SOG1) that governs DNA damage responses such as cell cycle arrest, stem cell death, and early onset of endoreplication. However, molecular mechanisms underlying the early induction of endoreplication onset in response to DNA damage remain elusive. In this study, we show that CELL CYCLE SWITCH 52 A1 (CCS52A1), an activator of the APC/C E3 ligase, plays a major role in the early onset of endoreplication in response to DNA double-strand breaks (DSBs) in Arabidopsis roots. Upon DSBs, SOG1 directly binds to the CCS52A1 locus, thereby inducing its expression. Moreover, early transition to endoreplication in response to DSBs is suppressed in ccs52a1 knockout roots. Our data propose that increased polyploidy may function as a unique adaptative mechanism to genotoxic stress in plants. |
| 書誌情報 |
en : Journal of Plant Research
巻 138,
号 4,
p. 679-693,
ページ数 15,
発行日 2025-04-07
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| 出版者 |
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出版者 |
Springer |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
1618-0860 |
| 出版者版DOI |
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関連タイプ |
isReplacedBy |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1007/s10265-025-01630-y |
| 出版者版URI |
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関連タイプ |
isReplacedBy |
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識別子タイプ |
URI |
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関連識別子 |
https://link.springer.com/article/10.1007/s10265-025-01630-y |
| 権利 |
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権利情報Resource |
https://creativecommons.org/licenses/by/4.0/ |
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権利情報 |
© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
| 著者版フラグ |
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出版タイプ |
NA |
| 助成情報 |
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助成機関名 |
Meiji University |
| 助成情報 |
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助成機関名 |
Japan Society for the Promotion of Science (JSPS) |
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研究課題番号 |
22K06265 |
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研究課題番号URI |
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K06265/ |
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研究課題名 |
植物の組織再生を支える分子基盤の解明 |
| 助成情報 |
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助成機関名 |
Japan Society for the Promotion of Science (JSPS) |
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研究課題番号 |
22H04722 |
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研究課題番号URI |
https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-22H04722/ |
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研究課題名 |
根の成長を制御する周期と変調の分子基盤の解明 |
| 助成情報 |
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助成機関名 |
Japan Society for the Promotion of Science (JSPS) |
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研究課題番号 |
24K09509 |
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研究課題番号URI |
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K09509/ |
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研究課題名 |
重イオンマイクロビームを用いた局所的DNA損傷による幹細胞化プロセスの解明 |
