| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-11-14 |
| タイトル |
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タイトル |
PD-1 is conserved from sharks to humans: new insights into PD-1, PD-L1, PD-L2, and SHP-2 evolution |
| 言語 |
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言語 |
eng |
| キーワード |
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主題Scheme |
Other |
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主題 |
PD-1 |
| キーワード |
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主題Scheme |
Other |
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主題 |
PD-L1 |
| キーワード |
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主題Scheme |
Other |
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主題 |
PD-L2 |
| キーワード |
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主題Scheme |
Other |
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主題 |
SHP-1 |
| キーワード |
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主題Scheme |
Other |
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主題 |
SHP-2 |
| キーワード |
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主題Scheme |
Other |
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主題 |
SHP-2L |
| キーワード |
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主題Scheme |
Other |
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主題 |
evolution |
| キーワード |
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主題Scheme |
Other |
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主題 |
fish |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
Kondo, Ryohei
Kondo, Kohei
Nabeshima, Kei
Nishikimi, Akihiko
石田, 靖雅
重岡, 稔章
Dijkstra, Johannes M.
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Programmed cell death protein 1 (PD-1) is an immune checkpoint molecule until recently believed to exist only in tetrapod species. However, together with a very recent study dedicated to the CD28/CTLA4 molecule family, this study—using database information—identifies the PD-1 gene in both bony and cartilaginous fish, while being the first to present a detailed molecular analysis of the evolution of PD-1 and its ligands. Conserved sequence motifs imply an ancient origin of PD-1’s binding modes to its extracellular ligand PD-L1 and its intracellular ligand Src homology region 2 domain-containing phosphatase-2 (SHP-2), and also of its N116 glycosylation motif—a less well known PD-1 feature—important for binding galectins. The PD-1 cytoplasmic tail binds SHP-2 by two motifs, defined as an immunoreceptor tyrosine-based inhibitory motif (ITIM) and immunoreceptor tyrosine-based switch motif (ITSM), but sequence conservation patterns show that these definitions warrant a discussion. As in mammals, PD-1 transcripts in fish could be found co-expressed with markers of regulatory and exhausted T cells, suggesting a similar immune checkpoint function. Agreeing with previous reports, the PD-L1/PD-L2 gene duplication was only found in tetrapod species, while we newly discovered that features that consistently distinguish the two molecules are PD-L2 IgC domain motifs. Among PD-L1 (the name given to the single PD-L ancestral molecule) of many ray-finned fish, conservation of a very long cytoplasmic tail motif supports previous claims that PD-L1 cytoplasmic tails may have a function. Surprisingly, we found a gene similar to SHP-2—that we named SHP-2-like (SHP-2L)—to be conserved from sharks to mammals, although lost or inactivated in higher primates and rodents. SHP-2L is expected to bind PD-1 similar to SHP-2. This comparative analysis of PD-1 and its interacting molecules across jawed vertebrates highlights conserved immune checkpoint features while revealing new insights and lineage-specific adaptations. |
| 書誌情報 |
en : Frontiers in Immunology
巻 16,
ページ数 16,
発行日 2025-05-28
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| 出版者 |
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出版者 |
FRONTIERS MEDIA |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
1664-3224 |
| 出版者版DOI |
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関連タイプ |
isReplacedBy |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.3389/fimmu.2025.1573492 |
| 出版者版URI |
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関連タイプ |
isReplacedBy |
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識別子タイプ |
URI |
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関連識別子 |
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1573492/full |
| 権利 |
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権利情報Resource |
https://creativecommons.org/licenses/by/4.0/ |
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権利情報 |
© 2025 Kondo, Kondo, Nabeshima, Nishikimi, Ishida, Shigeoka and Dijkstra. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| 著者版フラグ |
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出版タイプ |
NA |
