| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-10-20 |
| 日付 |
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日付 |
2026-01-18 |
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日付タイプ |
Available |
| タイトル |
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タイトル |
The transmembrane protein TMEM196 controls cell proliferation and determines the floor plate cell lineage |
| 言語 |
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言語 |
eng |
| キーワード |
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主題Scheme |
Other |
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主題 |
chick embryo |
| キーワード |
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主題Scheme |
Other |
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主題 |
ES cell differentiation |
| キーワード |
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主題Scheme |
Other |
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主題 |
floor plate |
| キーワード |
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主題Scheme |
Other |
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主題 |
neural tube |
| キーワード |
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主題Scheme |
Other |
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主題 |
neuromesoderm |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
embargoed access |
| 著者 |
Matsumoto, Yumi
Tamaru, Seiichi
Chen, Xing
篠塚, 琢磨
作村, 諭一
笹井, 紀明
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
The neural tube, the embryonic precursor to the vertebrate central nervous system, comprises distinct progenitor and neuronal domains, each with specific proliferation programs. In this study, we identified TMEM196, a novel transmembrane protein that plays a crucial role in regulating cell proliferation in the floor plate in chick embryos. TMEM196 is expressed in the floor plate, and its overexpression leads to reduced cell proliferation without affecting the pattern formation of the neural tube. We also established the floor plate differentiation protocol of the mouse embryonic stem cells, and analyzed the function of TMEM196 with this system. Mutating the Tmem196 gene does not alter cell division and overall differentiation remains unchanged within the neural cells. However, TMEM196 inhibits Wnt signaling, and Tmem196 mutant cells exhibit aberrant paraxial mesoderm differentiation, suggesting that TMEM196 selects the floor plate cell fate at the binary decision of the neuromesodermal cells. These findings highlight TMEM196 as a key regulator of both cell proliferation and floor plate determination, contributing to proper regionalization during embryogenesis. |
| 書誌情報 |
en : Development, Growth and Differentiation
巻 67,
号 2,
p. 94-103,
ページ数 10,
発行日 2025-01-18
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| 出版者 |
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出版者 |
Wiley |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
1440-169X |
| 出版者版DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1111/dgd.12960 |
| 出版者版URI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
URI |
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関連識別子 |
https://onlinelibrary.wiley.com/doi/full/10.1111/dgd.12960 |
| 権利 |
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権利情報 |
© 2025 Japanese Society of Developmental Biologists. This is the peer reviewed version of the following article: Matsumoto Yumi, Tamaru Seiichi, Chen Xing, Shinozuka Takuma, Sakumura Yuichi, Sasai Noriaki, 2025.The transmembrane protein TMEM196 controls cell proliferation and determines the floor plate cell lineage. Development, Growth and Differentiation. 67, 2, 94-103, which has been published in final form at https://doi.org/10.1111/dgd.12960 . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. 出版社許諾条件により、本文は2026年1月18日以降に公開。 |
| 著者版フラグ |
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出版タイプ |
AM |
| 助成情報 |
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助成機関名 |
Japan Society for the Promotion of Science (JSPS) |
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研究課題番号 |
23K14196 |
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研究課題番号URI |
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K14196/ |
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研究課題名 |
グリア細胞の多様性が生み出される分子メカニズムとその生物学的意義 |
| 助成情報 |
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助成機関名 |
Japan Society for the Promotion of Science (JSPS) |
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研究課題番号 |
23H04707 |
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研究課題番号URI |
https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-23H04707/ |
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研究課題名 |
定量細胞モデルによる血管新生の秩序力学の解明 |
| 助成情報 |
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助成機関名 |
Japan Society for the Promotion of Science (JSPS) |
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研究課題番号 |
20H03263 |
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研究課題番号URI |
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H03263/ |
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研究課題名 |
パターン形成・増殖・分化タイミングの相互作用による中枢神経細胞の位置的・量的制御 |
| 助成情報 |
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助成機関名 |
Suzuken Memorial Foundation |
| 助成情報 |
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助成機関名 |
The Naito Foundation |
fulltext (372.6 KB)
