| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-10-08 |
| タイトル |
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タイトル |
Epigenetic regulation of neural stem cell aging in the mouse hippocampus by Setd8 downregulation |
| 言語 |
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言語 |
eng |
| キーワード |
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主題Scheme |
Other |
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主題 |
Neural Stem Cell |
| キーワード |
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主題Scheme |
Other |
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主題 |
Aging |
| キーワード |
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主題Scheme |
Other |
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主題 |
Epigenetics |
| キーワード |
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主題Scheme |
Other |
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主題 |
Hippocampus |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
松田, 泰斗
Matsubara, Shuzo
Matsuda-Ito, Kanae
Sekiryu, Haruka
Doi, Hiroyoshi
Nakagawa, Takumi
Murao, Naoya
Oda, Hisanobu
Nakashima, Kinichi
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Neural stem cells (NSCs) in the mammalian brain decline rapidly with age, leading to impairment of hippocampal memory function in later life. However, the relationship between epigenetic remodeling and transcriptional regulation that compromises hippocampal NSC activity during the early stage of chronological aging remains unclear. Here, we performed single-cell RNA sequencing (scRNA-seq) and single-cell ATAC sequencing (scATAC-seq) on NSCs and newly generated neurons across different stages. Integrated data analysis revealed continuous alterations in the chromatin profile of hippocampal NSCs and their progeny from neonatal to mature adult stages, accompanied by consistent changes in transcriptional profiles. Further, decreased expression of Setd8, encoding the enzyme for histone H4 monomethylation at lysine 20 (H4K20me1), underlies age-related changes in mouse hippocampal NSCs. Notably, depletion of Setd8 elicits alterations in gene expression and epigenetic regulation that phenocopy age-related changes, and impairs NSC activity, leading to hippocampal memory deficits. Together, our study provides a global map of longitudinal chromatin and transcriptome changes during brain aging and identifies mechanistic insights into early-onset decline of NSC activity and hippocampal neurogenesis that precedes functional aging. |
| 書誌情報 |
en : The EMBO Journal
巻 44,
号 13,
p. 3645-3668,
ページ数 24,
発行日 2025-07-01
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| 出版者 |
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出版者 |
John Wiley & Sons, Ltd. |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
1460-2075 |
| 出版者版DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1038/s44318-025-00455-8 |
| 出版者版URI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
URI |
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関連識別子 |
https://www.embopress.org/doi/full/10.1038/s44318-025-00455-8 |
| 権利 |
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権利情報Resource |
https://creativecommons.org/licenses/by/4.0/ |
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権利情報 |
© The Author(s). This article is licensed under a Creative Commons Attribution 4.0International License, which permits use, sharing, adaptation, distribution andreproduction in any medium or format, as long as you give appropriate credit tothe original author(s) and the source, provide a link to the Creative Commonslicence, and indicate if changes were made. The images or other third partymaterial in this article are included in the article’s Creative Commons licence,unless indicated otherwise in a credit line to the material. If material is notincluded in the article’s Creative Commons licence and your intended use is notpermitted by statutory regulation or exceeds the permitted use, you will need toobtain permission directly from the copyright holder. To view a copy of thislicence, visit http://creativecommons.org/licenses/by/4.0/. Creative Com-mons Public Domain Dedication waiver http://creativecommons.org/public-domain/zero/1.0/ applies to the data associated with this article, unlessotherwise stated in a credit line to the data, but does not extend to the graphicalor creative elements of illustrations, charts, or figures. This waiver removes legalbarriers to the re-use and mining of research data. According to standardscholarly practice, it is recommended to provide appropriate citation andattribution whenever technically possible. |
| 著者版フラグ |
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出版タイプ |
VoR |
| 助成情報 |
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助成機関名 |
The LiSCO at the Nara Institute of Science and Technology (NAIST) |
| 助成情報 |
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助成機関名 |
Japan Society for the Promotion of Science (JSPS) |
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研究課題番号 |
JP16H06527 |
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研究課題番号URI |
https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-16H06527/ |
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研究課題名 |
個性を創発する神経幹細胞におけるエピジェネティックメモリーとその制御 |
| 助成情報 |
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助成機関名 |
Japan Society for the Promotion of Science (JSPS) |
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研究課題番号 |
JP18K14820 |
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研究課題番号URI |
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K14820/ |
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研究課題名 |
神経幹細胞エイジングを誘発する最初期因子の同定 |
| 助成情報 |
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助成機関名 |
Japan Society for the Promotion of Science (JSPS) |
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研究課題番号 |
JP21H02808 |
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研究課題番号URI |
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H02808/ |
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研究課題名 |
腸内細菌による異所性ニューロン新生誘発の分子基盤解明とてんかん治療法創出 |
| 助成情報 |
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助成機関名 |
Japan Society for the Promotion of Science (JSPS) |
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研究課題番号 |
JP23K18451 |
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研究課題番号URI |
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K18451/ |
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研究課題名 |
幹細胞老化機構の解明とリプログラミングに基づく健康脳機能の再生 |
| 助成情報 |
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助成機関名 |
Japan Society for the Promotion of Science (JSPS) |
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研究課題番号 |
JP16H06279 |
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研究課題番号URI |
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H06279/ |
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研究課題名 |
先進ゲノム解析研究推進プラットフォーム |
| 助成情報 |
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助成機関名 |
Japan Society for the Promotion of Science (JSPS) |
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研究課題番号 |
JP20J20975 |
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研究課題番号URI |
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20J20975/ |
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研究課題名 |
加齢に伴う神経幹細胞機能低下の分子基盤解明とその改善法の創出 |
| 助成情報 |
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助成機関名 |
Nakajima Foundation |
| 助成情報 |
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助成機関名 |
Mochida Foundation |
| 助成情報 |
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助成機関名 |
Japan Science and Technology Agency (JST) |
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研究課題番号 |
JPMJFR231Z |
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研究課題番号URI |
https://projectdb.jst.go.jp/grant/JST-PROJECT-24014384/ |
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研究課題名 |
バリア機構打破によるヒト神経細胞への分化転換誘導と疾患治療 |
| 助成情報 |
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助成機関名 |
Japan Agency for Medical Research and Development（AMED） |
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研究課題番号 |
JP20gm1310008 |
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研究課題名 |
環境変化誘発性精神・神経疾患の発症共通原理の解明ならびに完全非侵襲的細胞置換による治療法の創出 |
| 助成情報 |
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助成機関名 |
Japan Agency for Medical Research and Development（AMED） |
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研究課題番号 |
JP24wm0625306 |
fulltext (4.2 MB)
