| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-09-29 |
| タイトル |
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|
タイトル |
Front-light Structure with Excitation Light Polarized for Enhancing Lensless Fluorescence Imaging |
| 言語 |
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|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
lensless imaging device |
| キーワード |
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|
主題Scheme |
Other |
|
主題 |
fluorescent imaging |
| キーワード |
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|
主題Scheme |
Other |
|
主題 |
front-light structure |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
diffractor |
| キーワード |
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|
主題Scheme |
Other |
|
主題 |
light-polarized |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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|
アクセス権 |
open access |
| 著者 |
Promking, Arphorn
Sunaga, Yoshinori
Ohta, Yasumi
岡田, 竜馬
Takehara, Hironari
Haruta, Makito
Tashiro, Hiroyuki
太田, 淳
笹川, 清隆
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
In this study, we introduce a high-performance front-light structure integrated with optical polarization control to improve low-contrast fluorescent imaging in lensless devices. Lensless fluorescence imaging is an advanced technology with the potential to enhance the performance of biological and neurological imaging. However, there are still challenges to achieving high image quality, particularly in low-contrast fluorescent signals due to light scattering and absorption. The performance of a low-fluorescence stripe diffractor, fabricated using Norland Optical Adhesive 63 (NOA 63), was evaluated in comparison to polydimethylsiloxane (PDMS) material as a light guide. The diffractor is designed to operate with a hybrid emission filter on the image sensor. As a result, by coupling a 450 nm laser with either P- or S-polarization, it was shown that NOA 63 is notable as a diffractor material. Notably, S-polarized light showed a great excitation intensity and an enhanced contrast in fluorescent bead imaging compared with P-polarized light. Furthermore, the system was validated for biological applications by successfully detecting fluorescent bead emission in agarose-embedded samples of various thicknesses, simulating brain tissue. These results emphasize the system’s ability to capture lowintensity fluorescence signals from deep layers of biological tissue. |
| 書誌情報 |
en : Sensors and Materials
巻 37,
号 4,
p. 1363-1381,
ページ数 19,
発行日 2025-04-03
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| 出版者 |
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出版者 |
MYU K.K. |
| ISSN |
|
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収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2435-0869 |
| 出版者版DOI |
|
|
関連タイプ |
isReplacedBy |
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|
識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.18494/SAM5600 |
| 出版者版URI |
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|
関連タイプ |
isReplacedBy |
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|
識別子タイプ |
URI |
|
|
関連識別子 |
https://sensors.myu-group.co.jp/article.php?ss=5600 |
| 権利 |
|
|
権利情報Resource |
https://creativecommons.org/licenses/by/4.0/ |
|
権利情報 |
© MYU K.K. This work is licensed under a Creative Commons Attribution 4.0 International License. |
| 著者版フラグ |
|
|
出版タイプ |
NA |
| 助成情報 |
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|
|
助成機関名 |
Japan Society for the Promotion of Science (JSPS) |
|
|
研究課題番号 |
JP21H03809 |
|
|
研究課題番号URI |
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K21853/ |
|
|
研究課題名 |
撮像面上励起光源と角度分解撮像による刺入型蛍光イメージングデバイスの高性能化 |
| 助成情報 |
|
|
|
助成機関名 |
Japan Society for the Promotion of Science (JSPS) |
|
|
研究課題番号 |
JP23K21853 |
|
|
研究課題番号URI |
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K21853/ |
|
|
研究課題名 |
撮像面上励起光源と角度分解撮像による刺入型蛍光イメージングデバイスの高性能化 |
| 助成情報 |
|
|
|
助成機関名 |
Japan Society for the Promotion of Science (JSPS) |
|
|
研究課題番号 |
JP23H05450 |
|
|
研究課題番号URI |
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23H05450/ |
|
|
研究課題名 |
早期診断と治療を一元化する埋植型光電子デバイス ～光電気薬学創成に向けて～ |
| 助成情報 |
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助成機関名 |
The Uehara Memorial Foundation |
| 助成情報 |
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|
助成機関名 |
Murata Foundation |
