| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-09-22 |
| タイトル |
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タイトル |
Small molecules and heat treatments reverse vernalization via epigenetic modification in Arabidopsis |
| 言語 |
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言語 |
eng |
| キーワード |
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主題Scheme |
Other |
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主題 |
Plant development |
| キーワード |
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主題Scheme |
Other |
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主題 |
Plant physiology |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
Otsuka, Nana
Yamaguchi, Ryoya
Sawa, Hikaru
Kadofusa, Naoya
Kato, Nanako
Nomura, Yasuyuki
山口, 暢俊
Nagano, Atsushi J.
Sato, Ayato
白川, 一
伊藤, 寿朗
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Monocarpic plants flower only once and then produce seeds. Many monocarpic plants require a cold treatment known as vernalization before they flower. This requirement delays flowering until the plant senses warm temperatures in the spring. Exposure to high temperatures following vernalization causes devernalization, which cancels the vernalized state, inhibiting flowering and promoting vegetative growth. In this study, we screened over 16,000 chemical compounds and identified five small molecules (devernalizers; DVRs) that induce devernalization in Arabidopsis thaliana at room temperature without requiring a high-temperature treatment. Treatment with DVRs reactivated the expression of FLOWERING LOCUS C (FLC), a master repressor of flowering, by reducing the deposition of repressive histone modifications, thereby delaying flowering time. Three of the DVRs identified shared two structures: a hydantoin-like region and a spiro-like carbon. Treatment with DVR06, which has a simple chemical structure containing these domains, delayed flowering time and reduced the deposition of repressive histone modifications at FLC. RNA-seq and ChIP-seq analyses revealed both shared and specific transcriptomic and epigenetic effects between DVR06- and heat-induced devernalization. Overall, our extensive chemical screening indicated that hydantoin and spiro are key chemical signatures that reduce repressive histone modifications and promote devernalization in plants. |
| 書誌情報 |
en : Communications Biology
巻 8,
号 1,
ページ数 11,
発行日 2025-01-22
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| 出版者 |
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出版者 |
Nature Research |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2399-3642 |
| 出版者版DOI |
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関連タイプ |
isReplacedBy |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1038/s42003-025-07553-7 |
| 出版者版URI |
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関連タイプ |
isReplacedBy |
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識別子タイプ |
URI |
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関連識別子 |
https://www.nature.com/articles/s42003-025-07553-7 |
| 権利 |
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権利情報Resource |
https://creativecommons.org/licenses/by/4.0/ |
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権利情報 |
© The Author(s) 2025. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
| 著者版フラグ |
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出版タイプ |
NA |
| 助成情報 |
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助成機関名 |
Nara Institute of Science and Technology |
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研究課題名 |
Nara Institute of Science and Technology (NAIST) University Fellowships for the Creation of Innovation in Science and Technology |
| 助成情報 |
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助成機関名 |
Japan Society for the Promotion of Science (JSPS) |
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研究課題番号 |
22H04723 |
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研究課題番号URI |
https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-22H04723/ |
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研究課題名 |
維管束-ミロシン細胞のワイヤリングにおけるオーキシンの作用機序 |
| 助成情報 |
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助成機関名 |
Japan Society for the Promotion of Science (JSPS) |
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研究課題番号 |
24H00881 |
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研究課題番号URI |
https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-24H00881/ |
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研究課題名 |
一細胞レベルでの高解像度発現解析と代謝産物の標的同定による天然物生物学 |
| 助成情報 |
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助成機関名 |
Takeda Science Foundation |
| 助成情報 |
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助成機関名 |
Japan Science and Technology Agency (JST) |
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研究課題番号 |
JPMJPR22D3 |
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研究課題番号URI |
https://projectdb.jst.go.jp/grant/JST-PROJECT-22715720/ |
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研究課題名 |
一細胞／一核RNA-seq解析による異形細胞の遺伝子発現アトラス |
| 助成情報 |
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助成機関名 |
Japan Society for the Promotion of Science (JSPS) |
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研究課題番号 |
18H02465 |
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研究課題番号URI |
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H02465/ |
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研究課題名 |
階層縦断的に機能するエピジェネティックバイオタイマーの仕組みの理解 |
| 助成情報 |
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助成機関名 |
Japan Society for the Promotion of Science (JSPS) |
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研究課題番号 |
23H02503 |
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研究課題番号URI |
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K27195/ |
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研究課題名 |
花弁基部の細胞動態に注目した脱離制御機構の解明 |
| 助成情報 |
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助成機関名 |
Japan Society for the Promotion of Science (JSPS) |
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研究課題番号 |
21H05663 |
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研究課題番号URI |
https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-21H05663/ |
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研究課題名 |
不規則な温度に対する植物の多層的レジリエンス機構 |
| 助成情報 |
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助成機関名 |
Japan Society for the Promotion of Science (JSPS) |
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研究課題番号 |
23H04968 |
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研究課題番号URI |
https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-23H04968/ |
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研究課題名 |
BVOC放出とストレス耐性を連動させるエピゲノム分子基盤の解明 |
| 助成情報 |
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助成機関名 |
Japan Science and Technology Agency (JST) |
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研究課題番号 |
JPMJFR210B |
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研究課題番号URI |
https://projectdb.jst.go.jp/grant/JST-PROJECT-21470425/ |
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研究課題名 |
野外トランスクリプトームの化学的制御手法の確立 |
| 助成情報 |
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助成機関名 |
Japan Society for the Promotion of Science (JSPS) |
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研究課題番号 |
JP20H00470 |
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研究課題番号URI |
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H00470/ |
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研究課題名 |
植物幹細胞の増殖・分化・老化のバランスによる花の数とサイズの制御機構 |
| 助成情報 |
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助成機関名 |
Japan Society for the Promotion of Science (JSPS) |
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研究課題番号 |
JP21K19266 |
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研究課題番号URI |
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K19266/ |
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研究課題名 |
近縁種交配体ゲノムによる植物個体死の定義および制御系の理解 |
| 助成情報 |
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助成機関名 |
Japan Society for the Promotion of Science (JSPS) |
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研究課題番号 |
JP22H05176 |
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研究課題番号URI |
https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-22H05176/ |
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研究課題名 |
両性花における動物を利用した他殖促進機構の構築原理 |
| 助成情報 |
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助成機関名 |
Ministry of Education, Culture, Sports, Science and Technology (MEXT) |
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研究課題名 |
World Premier International Research Center Initiative (WPI) |
