| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-07-15 |
| タイトル |
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タイトル |
Dual-Responsive Poly(N-Isopropylacrylamide) Hydrogel Loaded with Poly-l-Lactic Acid Microparticles Encapsulating Boesenbergia Rotunda Extract for Enhanced Topical Delivery |
| 言語 |
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言語 |
eng |
| キーワード |
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主題Scheme |
Other |
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主題 |
Betamethasone Dipropionate |
| キーワード |
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主題Scheme |
Other |
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主題 |
Boesenbergia Rotunda |
| キーワード |
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主題Scheme |
Other |
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主題 |
PH-Responsive |
| キーワード |
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主題Scheme |
Other |
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主題 |
Thermoresponsive |
| キーワード |
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主題Scheme |
Other |
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主題 |
Microparticles |
| キーワード |
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主題Scheme |
Other |
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主題 |
Hydrogels |
| キーワード |
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主題Scheme |
Other |
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主題 |
Atopic Dermatitis |
| キーワード |
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主題Scheme |
Other |
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主題 |
Anatomy |
| キーワード |
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主題Scheme |
Other |
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主題 |
Drug delivery |
| キーワード |
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主題Scheme |
Other |
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主題 |
Drug release |
| キーワード |
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主題Scheme |
Other |
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主題 |
Hydrogels |
| キーワード |
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主題Scheme |
Other |
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主題 |
Microparticles |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
Liana, Desy
網代, 広治
Chanthaset, Nalinthip
Phanumartwiwath, Anuchit
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
In response to the pH and temperature alterations characteristic of atopic dermatitis (AD), we developed a dual pH- and thermoresponsive hydrogel as a drug delivery system model. The thermoresponsive polymeric-based hydrogel incorporated pH-responsive microparticles encapsulating betamethasone dipropionate (BD) and hexane extract derived from Boesenbergia rotunda. PLLA-V6-OEG3 microparticles were prepared using an emulsification-solvent evaporation method, and their physicochemical properties were subsequently determined. Monodisperse spherical and negatively charged microparticles were obtained in the range of 1$20134 μm (polydispersity index, PDI < 0.5) with 98% BD encapsulation efficiency. Notably, the microparticles supplemented with the hexane extract (MP HE BD) exhibited the most rapid release under mildly acidic conditions (pH 6.0). Also, our drug carrier hydrogel was fabricated using poly(N-isopropylacrylamide) (PNIPAM) and N,N′-methylene bis acrylamide (BIS), which were cross-linked using a UV irradiation method. The PNIPAM-BIS hydrogel incorporated with particles demonstrated significant enhancements in both the swelling ratio (>600%) and swelling transition (>250%). The hydrogels were further investigated for ex vivo skin retention and permeation in AD-like mouse skin. The findings revealed that the formulated PNIPAM-BIS3 hydrogel loaded with MP HE BD microparticles facilitated the topical delivery of BD, resulting in a deposition of 31.01 ± 1.78 μg/cm2 on the mice’s skin. Remarkably, the addition of B. rotunda hexane extract, which mainly incorporated pinostrobin, was found to contribute to the topical release of BD. The PNIPAM-BIS3 hydrogel loaded with PLLA-V6-OEG3 microparticles supplemented with B. rotunda hexane extract holds promise as a smart dual-responsive drug carrier for managing AD skin conditions. |
| 書誌情報 |
en : ACS Applied Polymer Materials
巻 6,
号 15,
p. 9294-9305,
ページ数 12,
発行日 2024-08-09
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| 出版者 |
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出版者 |
American Chemical Society |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2637-6105 |
| 出版者版DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1021/acsapm.4c01716 |
| 出版者版URI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
URI |
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関連識別子 |
https://pubs.acs.org/doi/full/10.1021/acsapm.4c01716 |
| 権利 |
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権利情報Resource |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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権利情報 |
Copyright $00A9 2024 The Authors. Published by American Chemical Society. This article is licensed under CC-BY-NC-ND 4.0 . |
| 著者版フラグ |
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出版タイプ |
VoR |
| 助成情報 |
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助成機関名 |
Izumi Science and Technology Foundation |
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研究課題番号 |
2022-J081 |
| 助成情報 |
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助成機関名 |
Iketani Science and Technology Promotion
Foundation |
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研究課題番号 |
0351163-A |
| 助成情報 |
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助成機関名 |
Masuya Foundation |
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研究課題番号 |
2023011 |
fulltext (10.4 MB)
