| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-07-15 |
| 日付 |
|
|
日付 |
2026-11-20 |
|
日付タイプ |
Available |
| タイトル |
|
|
タイトル |
Particle behaviors of Imipenem/Cilastatin in various liquids investigated by chemical structures and temporal microscope observations |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Imipenem/Cilastatin |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Particle |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Hydrolysis |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Transcatheter arterial embolization (TAE) |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
embargoed access |
| 著者 |
Zhang, Rui
Chanthaset, Nalinthip
Sato, Takeshi
Iwakoshi, Shinichi
Horiuchi, Katsutoshi
Tanaka, Toshihiro
網代, 広治
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Imipenem/Cilastatin (IPM/CS) is currently used as an embolic agent in transarterial embolization for chronic musculoskeletal pain due to its efficacy of short-term blood flow occlusion. However, due to its off-label use, the development of new materials to substitute IPM/CS is needed. Therefore, investigating the behavior of IPM/CS particles becomes crucial. In this paper, we observed the changes in particle size of IPM/CS when dissolved in phosphate-buffered saline, normal saline, iodinated contrast agent and water. The results indicated that the particle size of IPM/CS ranged from 16 to 57$202F$00B5m and has fastest hydrolysis rate in iodinated contrast agent. And we analyzed the possible structure of hydrolyzed product of IPM/CS in water at room temperature and 37 ℃ using 1HNMR, HPLC. The results suggested Cilastatin is stable at both temperatures, while Imipenem hydrolyzed to produce slightly different products at different temperatures. |
| 書誌情報 |
en : Colloids and Surfaces A: Physicochemical and Engineering Aspects
巻 701,
ページ数 7,
発行日 2024-11-20
|
| 出版者 |
|
|
出版者 |
Elsevier |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
1873-4359 |
| 出版者版DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1016/j.colsurfa.2024.134896 |
| 出版者版URI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
URI |
|
|
関連識別子 |
https://www.sciencedirect.com/science/article/pii/S0927775724017606 |
| 権利 |
|
|
権利情報Resource |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
|
権利情報 |
$00A9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies. 出版社許諾条件により、本文は2026年11月20日以降に公開。 |
| 著者版フラグ |
|
|
出版タイプ |
AM |
| 助成情報 |
|
|
|
助成機関名 |
Koyanagi Foundation |
|
|
研究課題番号 |
23050066 |
| 助成情報 |
|
|
|
助成機関名 |
Japan Society for the Promotion of Science (JSPS) |
|
|
研究課題番号 |
JP24K10766 |
|
|
研究課題名 |
運動器慢性疼痛に対するカテーテル治療における新規血管塞栓粒子の開発 |
fulltext (1.3 MB)
