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アイテム
Cytokine-like-Vago-mediated antiviral response in Penaeus monodon via IKK-NF-κB signaling pathway
http://hdl.handle.net/10061/0002001045
http://hdl.handle.net/10061/0002001045e25a692d-fc07-4799-84b5-8c11770a03bd
| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||||||||||
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| 公開日 | 2025-07-10 | |||||||||||||||
| タイトル | ||||||||||||||||
| タイトル | Cytokine-like-Vago-mediated antiviral response in Penaeus monodon via IKK-NF-κB signaling pathway | |||||||||||||||
| 言語 | ||||||||||||||||
| 言語 | eng | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | Immunology | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | Virology | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||
| アクセス権 | ||||||||||||||||
| アクセス権 | open access | |||||||||||||||
| 著者 |
Nanakorn, Zittipong
× Nanakorn, Zittipong
× 河合, 太郎
× Tassanakajon, Anchalee
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| 抄録 | ||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||
| 内容記述 | Interferon (IFN) system is the primary mechanism of innate antiviral defense in immune response. To date, limited studies of IFN system were conducted in crustaceans. Previous report in Penaeus monodon demonstrated the interconnection of cytokine-like molecule Vago and inhibitor of kappa B kinase-nuclear factor κB (IKK-NF-κB) cascade against white spot syndrome virus (WSSV). This study further identified five different PmVago isoforms. Upon immune stimulation, PmVagos expressed against shrimp pathogens. PmVago1, PmVago4, and PmVago5 highly responded to WSSV, whereas, PmVago1 and PmVago4 RNAi exhibited a rapid mortality with elevated WSSV replication. Suppression of PmVago1 and PmVago4 negatively affected proPO system, genes in signal transduction, and AMPs. WSSV infection additionally induced PmVaog4 granule accumulation and cellular translocation to the area of cell membrane. More importantly, PmVago1 and PmVago4 promoters were stimulated by PmIKK overexpression; meanwhile, they further activated Dorsal and Relish promoter activities. These results suggested the possible roles of the cytokine-like PmVago via IKK-NF-κB cascade against WSSV infection. | |||||||||||||||
| 書誌情報 |
en : iScience 巻 27, 号 7, ページ数 21, 発行日 2024-07-19 |
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| 出版者 | Elsevier | |||||||||||||||
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| 収録物識別子タイプ | EISSN | |||||||||||||||
| 収録物識別子 | 2589-0042 | |||||||||||||||
| 出版者版DOI | ||||||||||||||||
| 関連タイプ | isReplacedBy | |||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||
| 関連識別子 | https://doi.org/10.1016/j.isci.2024.110161 | |||||||||||||||
| 出版者版URI | ||||||||||||||||
| 関連タイプ | isReplacedBy | |||||||||||||||
| 識別子タイプ | URI | |||||||||||||||
| 関連識別子 | https://www.sciencedirect.com/science/article/pii/S2589004224013865 | |||||||||||||||
| 権利 | ||||||||||||||||
| 権利情報Resource | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||||||||||||
| 権利情報 | $00A9 2024 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | |||||||||||||||
| 著者版フラグ | ||||||||||||||||
| 出版タイプ | NA | |||||||||||||||
| 助成情報 | ||||||||||||||||
| 助成機関名 | Chulalongkorn University | |||||||||||||||
| 研究課題名 | The Second Century Fund (C2F) | |||||||||||||||
| 助成情報 | ||||||||||||||||
| 助成機関名 | Chulalongkorn University | |||||||||||||||
| 研究課題名 | Thailand Science Research and Innovation Fund | |||||||||||||||
| 助成情報 | ||||||||||||||||
| 助成機関名 | Chulalongkorn University | |||||||||||||||
| 研究課題番号 | GCUGR1125652045D No. 1$201345 | |||||||||||||||
| 研究課題名 | The 90th Anniversary of Chulalongkorn University Fund (Ratchadaphiseksomphot Endowment Fund) | |||||||||||||||
| 助成情報 | ||||||||||||||||
| 助成機関名 | Chulalongkorn University | |||||||||||||||
| 研究課題名 | Ratchadaphiseksomphot Endowment | |||||||||||||||
