| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-07-10 |
| 日付 |
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日付 |
2025-12-09 |
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日付タイプ |
Available |
| タイトル |
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タイトル |
Fission yeast Pib2 localizes to vacuolar membranes and regulates TOR complex 1 through evolutionarily conserved domains |
| 言語 |
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言語 |
eng |
| キーワード |
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主題Scheme |
Other |
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主題 |
$FB01ssion yeast |
| キーワード |
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主題Scheme |
Other |
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主題 |
Pib2 |
| キーワード |
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主題Scheme |
Other |
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主題 |
TOR complex 1 |
| キーワード |
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主題Scheme |
Other |
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主題 |
vacuolar membrane |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
embargoed access |
| 著者 |
両角, 佑一
Hayashi, Yumi
Chu, Cuong Minh
Sofyantoro, Fajar
Akikusa, Yutaka
Fukuda, Tomoyuki
塩﨑, 一裕
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
TOR complex 1 (TORC1) is a multi-protein kinase complex that coordinates cellular growth with environmental cues. Recent studies have identified Pib2 as a critical activator of TORC1 in budding yeast. Here, we show that loss of Pib2 causes severe growth defects in fission yeast cells, particularly when basal TORC1 activity is diminished by hypomorphic mutations in tor2, the gene encoding the catalytic subunit of TORC1. Consistently, TORC1 activity is significantly compromised in the tor2 hypomorphic mutants lacking Pib2. Moreover, as in budding yeast, fission yeast Pib2 localizes to vacuolar membranes via its FYVE domain, with its tail motif indispensable for TORC1 activation. These results strongly suggest that Pib2-mediated positive regulation of TORC1 is evolutionarily conserved between the two yeast species. |
| 書誌情報 |
en : FEBS Letters
巻 598,
号 23,
p. 2886-2896,
ページ数 11,
発行日 2024-12-09
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| 出版者 |
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出版者 |
Wiley |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
1873-3468 |
| 出版者版DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1002/1873-3468.14980 |
| 出版者版URI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
URI |
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関連識別子 |
https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1873-3468.14980 |
| 権利 |
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権利情報 |
$00A92024 Federation of European Biochemical Societies. This is the peer reviewed version of the following article: Morozumi Yuich, Hayashi Yumi, Chu Cuong Minh, Sofyantoro Fajar, Akikusa Yutaka, Fukuda Tomoyuki, Shiozaki Kazuhiro. 2024. Fission yeast Pib2 localizes to vacuolar membranes and regulates TOR complex 1 through evolutionarily conserved domains. FEBS Letters. 598, 23, 2886-2896. which has been published in final form at https://doi.org/10.1002/1873-3468.14980 . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. 出版社許諾条件により、本文は2025年12月9日以降に公開。 |
| 著者版フラグ |
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出版タイプ |
AM |
| 助成情報 |
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助成機関名 |
Institute for Fermentation, Osaka |
| 助成情報 |
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助成機関名 |
Takeda Science Foundation |
| 助成情報 |
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助成機関名 |
Sumitomo Foundation |
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研究課題番号 |
2200364 |
| 助成情報 |
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助成機関名 |
Ohsumi Frontier Science Foundation |
| 助成情報 |
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助成機関名 |
Japan Society for the Promotion of Science (JSPS) |
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研究課題番号 |
19K06564 |
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研究課題名 |
進化的に保存されたmTORC1キナーゼ複合体を介したシグナル経路の分子機構解明 |
| 助成情報 |
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助成機関名 |
Japan Society for the Promotion of Science (JSPS) |
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研究課題番号 |
22K06145 |
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研究課題名 |
細胞成長を司るmTORC1キナーゼ複合体の活性制御機構の解明 |
| 助成情報 |
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助成機関名 |
Japan Society for the Promotion of Science (JSPS) |
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研究課題番号 |
19H03224 |
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研究課題名 |
栄養レベルに応答して寿命を調節する細胞内情報ネットワークの研究 |
| 助成情報 |
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助成機関名 |
Japan Society for the Promotion of Science (JSPS) |
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研究課題番号 |
20K06552 |
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研究課題名 |
選択的オートファジーによるオルガネラ分解の機構と意義の解明 |
| 助成情報 |
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助成機関名 |
Japan Society for the Promotion of Science (JSPS) |
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研究課題番号 |
23K05679 |
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研究課題名 |
オルガネラを選択的オートファジーで分解する機構と生理的意義 |
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