| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-07-08 |
| タイトル |
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タイトル |
Astrocyte-Specific Inhibition of the Primary Cilium Suppresses C3 Expression in Reactive Astrocyte |
| 言語 |
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言語 |
eng |
| キーワード |
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主題Scheme |
Other |
|
主題 |
Primary cilium |
| キーワード |
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|
主題Scheme |
Other |
|
主題 |
LPS |
| キーワード |
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|
主題Scheme |
Other |
|
主題 |
Astrocytes |
| キーワード |
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|
主題Scheme |
Other |
|
主題 |
Conditional knockout mouse |
| キーワード |
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主題Scheme |
Other |
|
主題 |
TRPV4 |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
Muhamad, Nor Atiqah
Masutani, Kohei
Furukawa, Shota
Yuri, Shunsuke
Toriyama, Michinori
Matsumoto, Chuya
Itoh, Seiya
Shinagawa, Yuichiro
磯谷, 綾子
Toriyama, Manami
伊東, 広
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
C3-positive reactive astrocytes play a neurotoxic role in various neurodegenerative diseases. However, the mechanisms controlling C3-positive reactive astrocyte induction are largely unknown. We found that the length of the primary cilium, a cellular organelle that receives extracellular signals was increased in C3-positive reactive astrocytes, and the loss or shortening of primary cilium decreased the count of C3-positive reactive astrocytes. Pharmacological experiments suggested that Ca2+ signalling may synergistically promote C3 expression in reactive astrocytes. Conditional knockout (cKO) mice that specifcally inhibit primary cilium formation in astrocytes upon drug stimulation exhibited a reduction in the proportions of C3-positive reactive astrocytes and apoptotic cells in the brain even after the injection of lipopolysaccharide (LPS). Additionally, the novel object recognition (NOR) score observed in the cKO mice was higher than that observed in the neuroinfammation model mice. These results suggest that the primary cilium in astrocytes positively regulates C3 expression. We propose that regulating astrocyte-specifc primary cilium signalling may be a novel strategy for the suppression of neuroinfammation. |
| 書誌情報 |
en : Cellular and Molecular Neurobiology
巻 44,
号 48,
ページ数 16,
発行日 2024-06-01
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| 出版者 |
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出版者 |
Speinger |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
1573-6830 |
| 出版者版DOI |
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関連タイプ |
isReplacedBy |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1007/s10571-024-01482-5 |
| 出版者版URI |
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関連タイプ |
isReplacedBy |
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識別子タイプ |
URI |
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関連識別子 |
https://link.springer.com/article/10.1007/s10571-024-01482-5 |
| 権利 |
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|
権利情報Resource |
https://creativecommons.org/licenses/by/4.0/ |
|
権利情報 |
$00A9 The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
| 著者版フラグ |
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出版タイプ |
NA |
| 助成情報 |
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助成機関名 |
Japan Society for the Promotion of Science (JSPS) |
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|
研究課題番号 |
JP21K15087 |
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研究課題名 |
一次繊毛シグナルに着目したA1アストロサイト分化制御機構の解明 |
| 助成情報 |
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助成機関名 |
Japan Society for the Promotion of Science (JSPS) |
|
|
研究課題番号 |
JP21K06382 |
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研究課題名 |
一次繊毛を基軸とした神経回路網形成機構の解明 |
| 助成情報 |
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|
助成機関名 |
Japan Society for the Promotion of Science (JSPS) |
|
|
研究課題番号 |
JP21K06837 |
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|
研究課題名 |
神経炎症における傷害性アストロサイト一次繊毛の形成と機能の解明 |
| 助成情報 |
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助成機関名 |
Naito Foundation（内藤記念科学振興財団） |
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研究課題名 |
神経炎症性アストロサイトを制御する一次繊毛シグナルの同定及び機能解析 |
