| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-06-19 |
| タイトル |
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タイトル |
Brain-implantable needle-type CMOS imaging device enables multi-layer dissection of seizure calcium dynamics in the hippocampus |
| 言語 |
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言語 |
eng |
| キーワード |
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主題Scheme |
Other |
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主題 |
brain-implantable devices |
| キーワード |
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主題Scheme |
Other |
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主題 |
CMOS image sensor |
| キーワード |
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主題Scheme |
Other |
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主題 |
calcium imaging |
| キーワード |
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主題Scheme |
Other |
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主題 |
temporal lobe epilepsy |
| キーワード |
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主題Scheme |
Other |
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主題 |
seizure, hippocampus |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
Olorocisimo, Joshua Philippe
Ohta, Yasumi
Regonia, Paul R
Castillo, Virgil C G
Yoshimoto, Junichiro
Takehara, Hironari
笹川, 清隆
太田, 淳
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Objective: Current neuronal imaging methods mostly use bulky lenses that either impede animal behavior or prohibit multi-depth imaging. To overcome these limitations, we developed a lightweight lensless biophotonic system for neuronal imaging, enabling compact and simultaneous visualization of multiple brain layers. Approach: Our developed 'CIS-NAIST' device integrates a micro-CMOS image sensor, thin-film fluorescence filter, micro-LEDs, and a needle-shaped flexible printed circuit. With this device, we monitored neuronal calcium dynamics during seizures across the different layers of the hippocampus and employed machine learning techniques for seizure classification and prediction. Main results: The CIS-NAIST device revealed distinct calcium activity patterns across the CA1, molecular interlayer, and dentate gyrus. Our findings indicated an elevated calcium amplitude activity specifically in the dentate gyrus compared to other layers. Then, leveraging the multi-layer data obtained from the device, we successfully classified seizure calcium activity and predicted seizure behavior using Long Short-Term Memory and Hidden Markov models. Significance: Taken together, our 'CIS-NAIST' device offers an effective and minimally invasive method of seizure monitoring that can help elucidate the mechanisms of temporal lobe epilepsy. |
| 書誌情報 |
en : Journal of Neural Engineering
巻 21,
号 4,
発行日 2024-07-17
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| 出版者 |
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出版者 |
IOP Publishing |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
1741-2552 |
| 出版者版DOI |
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関連タイプ |
isReplacedBy |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1088/1741-2552/ad5c03 |
| 出版者版URI |
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関連タイプ |
isReplacedBy |
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識別子タイプ |
URI |
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関連識別子 |
https://iopscience.iop.org/article/10.1088/1741-2552/ad5c03 |
| 権利 |
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権利情報Resource |
https://creativecommons.org/licenses/by/4.0/ |
|
権利情報 |
$00A9 2024 The Author(s). Original content from this work may be used under the terms of the Creative Commons Attribution 4.0 license. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI. |
| 著者版フラグ |
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出版タイプ |
NA |
| 助成情報 |
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助成機関名 |
Japan Society for the Promotion of Science (JSPS) |
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研究課題番号 |
JP23H05450 |
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研究課題名 |
早期診断と治療を一元化する埋植型光電子デバイス ～光電気薬学創成に向けて～ |
| 助成情報 |
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助成機関名 |
VLSI Design and Education Center, University of Tokyo |
| 助成情報 |
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助成機関名 |
Cadence Design Systems, Inc. |
