| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-06-18 |
| タイトル |
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タイトル |
Laser-carbonized Electrodes on Implantable CMOS-based Imaging Device for Simultaneous Deep-brain Optical and Electrophysiological Measurements |
| 言語 |
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言語 |
eng |
| キーワード |
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主題Scheme |
Other |
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主題 |
laser carbonization |
| キーワード |
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主題Scheme |
Other |
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主題 |
electrophysiology |
| キーワード |
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主題Scheme |
Other |
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主題 |
calcium imaging |
| キーワード |
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主題Scheme |
Other |
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主題 |
CMOS |
| キーワード |
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主題Scheme |
Other |
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主題 |
hippocampus |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
Castillo, Virgil Christian G.
Tso, Kuang-Chih
Okada, Ryoma
Ohta, Yasumi
Sunaga, Yoshinori
笹川, 清隆
太田, 淳
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Optical and electrophysiological methods are widely used in neuroscience to study brain activity. Each technique has its own strengths and weaknesses that complement each other to provide a more comprehensive understanding of neuronal activity. To this end, we developed an implantable CMOS image sensor device with an integrated carbon electrode for the simultaneous measurement of fluorescence and extracellular signals. The device is composed of a 450 × 1660 $00B5m CMOS chip and micro-LED secured to a flexible printed circuit substrate. The chip has an imaging surface measuring 900 × 300 $00B5m2, comprising 120 × 90 pixels recording at 10 frames per second. An absorption filter film was placed on top of the imaging surface to block excitation light. The device was coated with parylene-C for waterproofing and, finally, the coating film was readily turned into carbon electrodes by laser carbonization. We characterized the laser-carbonized electrodes by cyclic voltammetry, electrochemical impedance spectroscopy, and X-ray photoelectron spectroscopy to confirm the electrode carbonization. We then demonstrated the simultaneous in vivo recording of fluorescence and extracellular signals in hippocampus CA1 using the device. |
| 書誌情報 |
en : Sensors and Materials
巻 36,
号 7,
p. 2735-2751,
発行日 2024-07-12
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| 出版者 |
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出版者 |
MYU K.K. |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2435-0869 |
| 出版者版DOI |
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関連タイプ |
isReplacedBy |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.18494/SAM5145 |
| 出版者版URI |
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関連タイプ |
isReplacedBy |
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識別子タイプ |
URI |
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関連識別子 |
https://sensors.myu-group.co.jp/article.php?ss=5145 |
| 権利 |
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権利情報Resource |
https://creativecommons.org/licenses/by/4.0/ |
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権利情報 |
$00A9 MYU K.K. This work is licensed under a Creative Commons Attribution 4.0 International License. |
| 著者版フラグ |
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出版タイプ |
NA |
| 助成情報 |
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助成機関名 |
Japan Society for the Promotion of Science (JSPS) |
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研究課題番号 |
JP23H05450 |
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研究課題名 |
早期診断と治療を一元化する埋植型光電子デバイス ～光電気薬学創成に向けて～ |
| 助成情報 |
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助成機関名 |
VLSI Design and Education Center, University of Tokyo |
| 助成情報 |
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助成機関名 |
Cadence Design Systems, Inc. |
