| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-06-17 |
| タイトル |
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タイトル |
Effects of Long-Term In vivo Stimulation on the Electrochemical Properties of a Porous Stimulation Electrode for a Suprachoroidal$2013Transretinal Stimulation (STS) Retinal Prosthesis |
| 言語 |
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言語 |
eng |
| キーワード |
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主題Scheme |
Other |
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主題 |
porous stimulation electrode |
| キーワード |
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主題Scheme |
Other |
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主題 |
retinal prosthesis |
| キーワード |
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主題Scheme |
Other |
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主題 |
electrochemical impedance spectroscopy |
| キーワード |
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主題Scheme |
Other |
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主題 |
equivalent circuit analysis |
| キーワード |
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主題Scheme |
Other |
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主題 |
suprachoroidal$2013transretinal stimulation |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
Nomura, Shuhei
Tashiro, Hiroyuki
Terasawa, Yasuo
Nakano, Yukari
Haruta, Makito
笹川, 清隆
Takehara, Hironari
Morimoto, Takeshi
Fujikado, Takashi
太田, 淳
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
A high-performance porous stimulation electrode [femtosecond laser-induced porosity (FLiP) electrode] was designed for the safe and effective delivery of high stimulation currents. Herein, we evaluated the electrochemical properties of the FLiP electrode interface under prolonged in vivo stimulation. The FLiP electrodes were surgically implanted in rabbits and subjected to stimulation currents over a six-month period. The impedance of these electrodes was examined through equivalent circuit analysis, specifically employing the Randles circuit model. Comparative analysis with the results of previous in vitro/in vivo studies was conducted. Electrical stimulation served to purify the electrode interface, enhancing mass diffusion and promoting charge-transfer reactions at the electrode interface. As a result, the electric double-layer capacitance (Cdl) could be enhanced by adjusting the ionic concentration at the electrode. The high charge injection capacity of the FLiP electrode is facilitated by not only capacitive currents resulting from Cdl but also pseudocapacitive currents stemming from the reversible redox reaction of H2 molecules. Our findings suggest that the initial evaluation outcomes can extrapolate the electrode properties during long-term stimulation, and the combined method of electrochemical impedance spectroscopy and equivalent circuit analysis clarifies intricate in vivo interactions, allowing accurate analysis of the properties of implantable electrodes over extended periods. |
| 書誌情報 |
en : Sensors and Materials
巻 35,
号 11,
p. 3567-3584,
発行日 2023-11-08
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| 出版者 |
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出版者 |
MYU K.K. |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2435-0869 |
| 出版者版DOI |
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関連タイプ |
isReplacedBy |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.18494/SAM4619 |
| 出版者版URI |
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関連タイプ |
isReplacedBy |
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識別子タイプ |
URI |
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関連識別子 |
https://sensors.myu-group.co.jp/article.php?ss=4619 |
| 権利 |
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権利情報Resource |
https://creativecommons.org/licenses/by/4.0/ |
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権利情報 |
$00A9 MYU K.K. This work is licensed under a Creative Commons Attribution 4.0 International License. |
| 著者版フラグ |
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出版タイプ |
NA |
| 助成情報 |
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助成機関名 |
AMED |
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研究課題番号 |
JP22gm1510010 |
