| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-06-11 |
| タイトル |
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|
タイトル |
Induction of Endoplasmic Reticulum Stress by Prodigiosin in Yeast Saccharomyces cerevisiae |
| 言語 |
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|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
prodigiosin |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
bacterial secondary metabolite |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
endoplasmic reticulum stress |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
unfolded-protein response |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
ROS |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
yeast |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Saccharomyces cerevisiae |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
| 著者 |
Nguyen, Sy Le Thanh
Nguyen, Thi Hien Trang
Do, Thi Tuyen
Nguyen, Thi Thao
Le, Thanh Hoang
Nguyen, Thi Anh Tuyet
木俣, 行雄
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Prodigiosin, a red pigment produced by numerous bacterial species, exerts various antibiotic effects on prokaryotic and eukaryotic organisms. For instance, human carcinoma cell lines appear to suffer from endoplasmic reticulum (ER) stress in the presence of prodigiosin. Here, we demonstrated that prodigiosin also triggers the unfolded-protein response (UPR), which is a cytoprotective response against ER stress, in yeast Saccharomyces cerevisiae. An S. cerevisiae mutant carrying a UPR-deficient mutation was hypersensitive to prodigiosin. Our observations cumulatively indicate that protein folding in the ER is impaired by prodigiosin, illustrating a new mode of action. |
| 書誌情報 |
en : Current Issues in Molecular Biology
巻 46,
号 3,
p. 1768-1776,
ページ数 9,
発行日 2024-02-26
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| 出版者 |
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出版者 |
MDPI |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
1467-3045 |
| 出版者版DOI |
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|
関連タイプ |
isReplacedBy |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.3390/cimb46030116 |
| 出版者版URI |
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関連タイプ |
isReplacedBy |
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|
識別子タイプ |
URI |
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|
関連識別子 |
https://www.mdpi.com/1467-3045/46/3/116 |
| 権利 |
|
|
権利情報Resource |
https://creativecommons.org/licenses/by/4.0/ |
|
権利情報 |
$00A9 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| 著者版フラグ |
|
|
出版タイプ |
NA |
| 助成情報 |
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|
助成機関名 |
National Foundation for Science and Technology Development (NAFOSTED) |
|
|
研究課題番号 |
106.02-2018.332 |
|
|
研究課題名 |
Renovated for higher-yield prodigiosin production from Serratia marcescens in Vietnam and identification of the molecular-biological mechanism by which prodigiosin works to cells |
