| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-05-02 |
| タイトル |
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タイトル |
DNA double-strand breaks enhance brassinosteroid signaling to activate quiescent center cell division in Arabidopsis |
| 言語 |
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言語 |
eng |
| キーワード |
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主題Scheme |
Other |
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主題 |
Brassinosteroid |
| キーワード |
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主題Scheme |
Other |
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主題 |
BRL3 |
| キーワード |
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主題Scheme |
Other |
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主題 |
DNA damage |
| キーワード |
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主題Scheme |
Other |
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主題 |
ERF115 |
| キーワード |
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主題Scheme |
Other |
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主題 |
quiescent center |
| キーワード |
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主題Scheme |
Other |
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主題 |
regeneration |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
Takahashi, Naoki
Suita, Kazuki
Koike, Toshiya
Ogita, Nobuo
Zhang, Ye
梅田, 正明
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
In Arabidopsis roots, the quiescent center (QC), a group of slowly dividing cells located at the center of the stem cell niche, functions as an organizing center to maintain the stemness of neighboring cells. Recent studies have shown that they also act as a reservoir for backup cells, which replenish DNA-damaged stem cells by activating cell division. The latter function is essential for maintaining stem cells under stressful conditions, thereby guaranteeing post-embryonic root development in fluctuating environments. In this study, we show that one of the brassinosteroid receptors in Arabidopsis, BRASSINOSTEROID INSENSITIVE1-LIKE3 (BRL3), plays a major role in activating QC division in response to DNA double-strand breaks. SUPPRESSOR OF GAMMA RESPONSE 1, a master transcription factor governing DNA damage response, directly induces BRL3. DNA damage-induced QC division was completely suppressed in brl3 mutants, whereas QC-specific overexpression of BRL3 activated QC division. Our data also showed that BRL3 is required to induce the AP2-type transcription factor ETHYLENE RESPONSE FACTOR 115, which triggers regenerative cell division. We propose that BRL3-dependent brassinosteroid signaling plays a unique role in activating QC division and replenishing dead stem cells, thereby enabling roots to restart growing after recovery from genotoxic stress. |
| 書誌情報 |
en : Journal of Experimental Botany
巻 75,
号 5,
p. 1364-1375,
発行日 2024-02-28
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| 出版者 |
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出版者 |
Oxford University Press |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
1460-2431 |
| 出版者版DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1093/jxb/erad424 |
| 出版者版URI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
URI |
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関連識別子 |
https://academic.oup.com/jxb/article/75/5/1364/7330313 |
| 権利 |
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権利情報 |
$00A9 The Author(s) 2023. This is a pre-copyedited, author-produced version of an article accepted for publication in Journal of Experimental Botany following peer review. The version of record Takahashi Naoki, Suita Kazuki, Koike Toshiya, Ogita Nobuo, Zhang Ye, Umeda Masaaki. DNA double-strand breaks enhance brassinosteroid signaling to activate quiescent center cell division in Arabidopsis. Journal of Experimental Botany 75, 5 is available online at: https://doi.org/10.1093/jxb/erad424. |
| 著者版フラグ |
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出版タイプ |
AM |
| 助成情報 |
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助成機関名 |
Ministry of Education, Culture, Sports, Science and Technology (MEXT) |
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研究課題番号 |
17H06470 |
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研究課題名 |
植物の生命力を支える多能性幹細胞の基盤原理 |
| 助成情報 |
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助成機関名 |
Ministry of Education, Culture, Sports, Science and Technology (MEXT) |
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研究課題番号 |
17H06477 |
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研究課題名 |
多能性幹細胞の維持・再生機構の解明 |
| 助成情報 |
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助成機関名 |
Ministry of Education, Culture, Sports, Science and Technology (MEXT) |
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研究課題番号 |
21H04715 |
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研究課題名 |
DNA倍加誘導に必要なクロマチン制御系の解明 |
| 助成情報 |
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助成機関名 |
Ministry of Education, Culture, Sports, Science and Technology (MEXT) |
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研究課題番号 |
22H04904 |
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研究課題名 |
植物の生命力を支える多能性幹細胞の基盤原理 |
| 助成情報 |
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助成機関名 |
Ministry of Education, Culture, Sports, Science and Technology (MEXT) |
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研究課題番号 |
19K06708 |
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研究課題名 |
ストレスに応答した植物の細胞周期停止を制御する分子基盤の解明 |
| 助成情報 |
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助成機関名 |
Ministry of Education, Culture, Sports, Science and Technology (MEXT) |
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研究課題番号 |
22H04722 |
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研究課題名 |
根の成長を制御する周期と変調の分子基盤の解明 |
| 助成情報 |
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助成機関名 |
Ministry of Education, Culture, Sports, Science and Technology (MEXT) |
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研究課題番号 |
22K06265 |
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研究課題名 |
植物の組織再生を支える分子基盤の解明 |
| 助成情報 |
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助成機関名 |
Ministry of Education, Culture, Sports, Science and Technology (MEXT) |
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研究課題番号 |
22K15143 |
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研究課題名 |
Study on brassinosteroid-mediated regulation of stem cell regeneration in roots |
fulltext (7.7 MB)
