WEKO3
アイテム
Development and validation of an open-source tool for opportunistic screening of osteoporosis from hip CT images
http://hdl.handle.net/10061/0002000791
http://hdl.handle.net/10061/000200079138a9ab34-e124-422c-9bf4-78b82c304714
| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2025-02-28 | |||||||||||||||||||||
| タイトル | ||||||||||||||||||||||
| タイトル | Development and validation of an open-source tool for opportunistic screening of osteoporosis from hip CT images | |||||||||||||||||||||
| 言語 | ||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | Osteoporosis | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | Artificial intelligence | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | Bone mineral density | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | hips | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | bone mineral density (BMD) | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | proximal femur | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | dual-energy X-ray absorptiometry | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | femora | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | hip surgery | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | clinicians | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | lesser trochanter | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | correlation coefficients | |||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||
| アクセス権 | ||||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||||
| 著者 |
Uemura, Keisuke
× Uemura, Keisuke
× 大竹, 義人× Takashima, Kazuma
× Hamada, Hidetoshi
× Imagama, Takashi
× Takao, Masaki
× Sakai, Takashi
× 佐藤, 嘉伸× Okada, Seiji
× Sugano, Nobuhiko
|
|||||||||||||||||||||
| 抄録 | ||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||
| 内容記述 | Aims This study aimed to develop and validate a fully automated system that quantifies proximal femoral bone mineral density (BMD) from CT images. Methods The study analyzed 978 pairs of hip CT and dual-energy X-ray absorptiometry (DXA) measurements of the proximal femur (DXA-BMD) collected from three institutions. From the CT images, the femur and a calibration phantom were automatically segmented using previously trained deep-learning models. The Hounsfield units of each voxel were converted into density (mg/cm3). Then, a deep-learning model trained by manual landmark selection of 315 cases was developed to select the landmarks at the proximal femur to rotate the CT volume to the neutral position. Finally, the CT volume of the femur was projected onto the coronal plane, and the areal BMD of the proximal femur (CT-aBMD) was quantified. CT-aBMD correlated to DXA-BMD, and a receiver operating characteristic (ROC) analysis quantified the accuracy in diagnosing osteoporosis. Results CT-aBMD was successfully measured in 976/978 hips (99.8%). A significant correlation was found between CT-aBMD and DXA-BMD (r = 0.941; p < 0.001). In the ROC analysis, the area under the curve to diagnose osteoporosis was 0.976. The diagnostic sensitivity and specificity were 88.9% and 96%, respectively, with the cutoff set at 0.625 g/cm2. Conclusion Accurate DXA-BMD measurements and diagnosis of osteoporosis were performed from CT images using the system developed herein. As the models are open-source, clinicians can use the proposed system to screen osteoporosis and determine the surgical strategy for hip surgery. |
|||||||||||||||||||||
| 書誌情報 |
en : Bone & Joint Research 巻 12, 号 9, p. 590, ページ数 597, 発行日 2023-09-20 |
|||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||
| 出版者 | British Editorial Society of Bone and Joint Surgery | |||||||||||||||||||||
| ISSN | ||||||||||||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||||||||||||
| 収録物識別子 | 2046-3758 | |||||||||||||||||||||
| 出版者版DOI | ||||||||||||||||||||||
| 関連タイプ | isReplacedBy | |||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1302/2046-3758.129.BJR-2023-0115.R1 | |||||||||||||||||||||
| 出版者版URI | ||||||||||||||||||||||
| 関連タイプ | isReplacedBy | |||||||||||||||||||||
| 識別子タイプ | URI | |||||||||||||||||||||
| 関連識別子 | https://boneandjoint.org.uk/article/10.1302/2046-3758.129.BJR-2023-0115.R1 | |||||||||||||||||||||
| 権利 | ||||||||||||||||||||||
| 権利情報Resource | https://creativecommons.org/licenses/by/4.0/ | |||||||||||||||||||||
| 権利情報 | $00A9 2023 Author(s) et al. Open Access This article is distributed under the terms of the Creative Commons Attributions (CC BY 4.0) licence (https://creativecommons.org/ licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original author and source are credited. | |||||||||||||||||||||
| 著者版フラグ | ||||||||||||||||||||||
| 出版タイプ | NA | |||||||||||||||||||||
