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pH Effect on Particle Aggregation of Vanillin End-Capped Polylactides Bearing a Hydrophilic Group Connected by a Cyclic Acetal Moiety
http://hdl.handle.net/10061/0002000740
http://hdl.handle.net/10061/00020007406cc8a0a4-85af-4639-bfa8-0547104eeae7
| 名前 / ファイル | ライセンス | アクション |
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fulltext (2.1 MB)
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| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||||||||
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| 公開日 | 2025-01-14 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | pH Effect on Particle Aggregation of Vanillin End-Capped Polylactides Bearing a Hydrophilic Group Connected by a Cyclic Acetal Moiety | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| キーワード | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | Aggregation | |||||||||||||
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| 主題Scheme | Other | |||||||||||||
| 主題 | Biopolymers | |||||||||||||
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| 主題Scheme | Other | |||||||||||||
| 主題 | Organic polymers | |||||||||||||
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| 主題Scheme | Other | |||||||||||||
| 主題 | Oxides | |||||||||||||
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| 主題Scheme | Other | |||||||||||||
| 主題 | Plastics | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ | journal article | |||||||||||||
| アクセス権 | ||||||||||||||
| アクセス権 | open access | |||||||||||||
| 著者 |
Sarisuta, Kamolchanok
× Sarisuta, Kamolchanok
× Iwami, Mizuho
× Mart$00EDn-Vaca, Blanca
× Chanthaset, Nalinthip
× 網代, 広治 |
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| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | To enhance the pH-responsiveness of poly(lactic acid) (PLA) particles, desired vanillin acetal-based initiators were synthesized and functional PLA was initiated at the chain end. PLLA-V6-OEG3 particles were prepared using polymers with various Mn values of 2400$20134800 g/mol. PLLA-V6-OEG3 was appropriated to achieve a pH-responsive behavior under physiological conditions within 3 min via the six-membered ring diol$2013ketone acetal. Moreover, it was found that the polymer chain length (Mn) influenced the aggregation rate. TiO2 was selected as the blending agent to improve the aggregation rate. The PLLA-V6-OEG3 blended with TiO2 was found to accelerate the aggregation rate compared with that without TiO2, and the best ratio of polymer/TiO2 was 1:1. To study the effect of the chain end for stereocomplex polylactide (SC-PLA) particles, PLLA-V6-OEG4 and PDLA-V6-OEG4 were successfully synthesized. The obtained results of SC-PLA particle aggregation implied that the types of chain end and the molecular weight of polymer could influence the aggregation rate. The SC-V6-OEG4 blended with TiO2 could not make our target to aggregate under physiological conditions within 3 min. This study motivated us to control the particle aggregation rate under physiological conditions for applying as a target drug carrier which is significantly influenced by not only the molecular weight but also the hydrophilicity of the chain-end as well as the number of acetal bonds. | |||||||||||||
| 書誌情報 |
en : Langmuir 巻 39, 号 11, p. 3994-4004, 発行日 2023-03-06 |
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| 出版者 | ||||||||||||||
| 出版者 | American Chemical Society | |||||||||||||
| ISSN | ||||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||||
| 収録物識別子 | 1520-5827 | |||||||||||||
| 出版者版DOI | ||||||||||||||
| 関連タイプ | isVersionOf | |||||||||||||
| 識別子タイプ | DOI | |||||||||||||
| 関連識別子 | https://doi.org/10.1021/acs.langmuir.2c03303 | |||||||||||||
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| 関連タイプ | isVersionOf | |||||||||||||
| 識別子タイプ | URI | |||||||||||||
| 関連識別子 | https://pubs.acs.org/doi/full/10.1021/acs.langmuir.2c03303 | |||||||||||||
| 権利 | ||||||||||||||
| 権利情報 | $00A9 2023 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Langmuir, copyright $00A9 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.langmuir.2c03303 | |||||||||||||
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| 出版タイプ | AM | |||||||||||||
