| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-12-02 |
| タイトル |
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|
タイトル |
Rapamycin-sensitive mechanisms confine the growth of fission yeast below the temperatures detrimental to cell physiology |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
両角, 佑一
Mahayot, Fontip
中瀬, 由起子
Soong, Jia Xin
Yamawaki, Sayaka
Sofyantoro, Fajar
Imabata, Yuki
Oda, Arisa H.
Tamura, Miki
Kofuji, Shunsuke
Akikusa, Yutaka
Shibatani, Ayu
Ohta, Kunihiro
塩﨑, 一裕
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Cells cease to proliferate above their growth-permissible temperatures, a ubiquitous phenomenon generally attributed to heat damage to cellular macromolecules. We here report that, in the presence of rapamycin, a potent inhibitor of Target of Rapamycin Complex 1 (TORC1), the fission yeast Schizosaccharomyces pombe can proliferate at high temperatures that usually arrest its growth. Consistently, mutations to the TORC1 subunit RAPTOR/Mip1 and the TORC1 substrate Sck1 significantly improve cellular heat resistance, suggesting that TORC1 restricts fission yeast growth at high temperatures. Aiming for a more comprehensive understanding of the negative regulation of high-temperature growth, we conducted genome-wide screens, which identified additional factors that suppress cell proliferation at high temperatures. Among them is Mks1, which is phosphorylated in a TORC1-dependent manner, forms a complex with the 14-3-3 protein Rad24, and suppresses the high-temperature growth independently of Sck1. Our study has uncovered unexpected mechanisms of growth restraint even below the temperatures deleterious to cell physiology. |
| 書誌情報 |
en : iScience
巻 27,
号 1,
発行日 2023-12-26
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| 出版者 |
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出版者 |
Elsevier |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2589-0042 |
| 出版者版DOI |
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関連タイプ |
isReplacedBy |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1016/j.isci.2023.108777 |
| 出版者版URI |
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関連タイプ |
isReplacedBy |
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識別子タイプ |
URI |
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関連識別子 |
https://www.sciencedirect.com/science/article/pii/S2589004223028547?via%3Dihub |
| 権利 |
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権利情報Resource |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
|
権利情報 |
c 2023 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| 著者版フラグ |
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出版タイプ |
NA |
