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Bayesian traction force estimation using cell boundary-dependent force priors
http://hdl.handle.net/10061/0002000654
http://hdl.handle.net/10061/0002000654f91885c8-0193-4c5d-b08a-959bfb86e8b2
| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||||||||
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| 公開日 | 2024-10-30 | |||||||||||||
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| タイトル | Bayesian traction force estimation using cell boundary-dependent force priors | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ | journal article | |||||||||||||
| アクセス権 | ||||||||||||||
| アクセス権 | open access | |||||||||||||
| 著者 |
Fujikawa, Ryosuke
× Fujikawa, Ryosuke
× Okimura, Chika
× Kozawa, Satoshi
× 池田, 和司× 稲垣, 直之× Iwadate, Yoshiaki
× 作村, 諭一 |
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| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Understanding the principles of cell migration necessitates measurements of the forces generated by cells. In traction force microscopy (TFM), fluorescent beads are placed on a substrate’s surface and the substrate strain caused by the cell traction force is observed as displacement of the beads. Mathematical analysis can estimate traction force from bead displacement. However, most algorithms estimate substrate stresses independently of cell boundary, which results in poor estimation accuracy in low-density bead environments. To achieve accurate force estimation at low density, we proposed a Bayesian traction force estimation (BTFE) algorithm that incorporates cell-boundary-dependent force as a prior. We evaluated the performance of the proposed algorithm using synthetic data generated with mathematical models of cells and TFM substrates. BTFE outperformed other methods, especially in low-density bead conditions. In addition, the BTFE algorithm provided a reasonable force estimation using TFM images from the experiment. | |||||||||||||
| 書誌情報 |
en : Biophysical Journal 巻 122, 号 23, p. 4542-4554, 発行日 2023-12-05 |
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| 出版者 | Elsevier | |||||||||||||
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| 収録物識別子タイプ | EISSN | |||||||||||||
| 収録物識別子 | 1542-0086 | |||||||||||||
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| 関連タイプ | isReplacedBy | |||||||||||||
| 識別子タイプ | DOI | |||||||||||||
| 関連識別子 | https://doi.org/10.1016/j.bpj.2023.10.032 | |||||||||||||
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| 関連タイプ | isReplacedBy | |||||||||||||
| 識別子タイプ | URI | |||||||||||||
| 関連識別子 | https://www.sciencedirect.com/science/article/pii/S0006349523006689?via%3Dihub | |||||||||||||
| 権利 | ||||||||||||||
| 権利情報Resource | http://creativecommons.org/licenses/by/4.0/ | |||||||||||||
| 権利情報 | c 2023 Biophysical Society. This is an open access article under the CC BY license (http:// creativecommons.org/licenses/by/4.0/). | |||||||||||||
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| 出版タイプ | NA | |||||||||||||
