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アイテム
Fundamental and Applicative Aspects of the Unfolded Protein Response in Yeasts
http://hdl.handle.net/10061/0002000573
http://hdl.handle.net/10061/0002000573b67637b5-5391-472e-aedc-c4f4f75f3410
| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2024-09-27 | |||||
| タイトル | ||||||
| タイトル | Fundamental and Applicative Aspects of the Unfolded Protein Response in Yeasts | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | yeast | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | endoplasmic reticulum | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | stress response | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | unfolded protein response | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| 著者 |
木俣, 有紀
× 木俣, 有紀× 木俣, 行雄 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Upon the dysfunction or functional shortage of the endoplasmic reticulum (ER), namely, ER stress, eukaryotic cells commonly provoke a protective gene expression program called the unfolded protein response (UPR). The molecular mechanism of UPR has been uncovered through frontier genetic studies using Saccharomyces cerevisiae as a model organism. Ire1 is an ER-located transmembrane protein that directly senses ER stress and is activated as an RNase. During ER stress, Ire1 promotes the splicing of HAC1 mRNA, which is then translated into a transcription factor that induces the expression of various genes, including those encoding ER-located molecular chaperones and protein modification enzymes. While this mainstream intracellular UPR signaling pathway was elucidated in the 1990s, new intriguing insights have been gained up to now. For instance, various additional factors allow UPR evocation strictly in response to ER stress. The UPR machineries in other yeasts and fungi, including pathogenic species, are another important research topic. Moreover, industrially beneficial yeast strains carrying an enforced and enlarged ER have been produced through the artificial and constitutive induction of the UPR. In this article, we review canonical and up-to-date insights concerning the yeast UPR, mainly from the viewpoint of the functions and regulation of Ire1 and HAC1. | |||||
| 書誌情報 |
en : Journal of Fungi 巻 9, 号 10, 発行日 2023-10-05 |
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| 出版者 | ||||||
| 出版者 | MDPI | |||||
| ISSN | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 2309-608X | |||||
| 出版者版DOI | ||||||
| 関連タイプ | isReplacedBy | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.3390/jof9100989 | |||||
| 権利 | ||||||
| 権利情報Resource | https://creativecommons.org/licenses/by/4.0/ | |||||
| 権利情報 | $00A9 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | |||||
| 著者版フラグ | ||||||
| 出版タイプ | NA | |||||
