| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-09-27 |
| タイトル |
|
|
タイトル |
Development and single-particle analysis of hybrid extracellular vesicles fused with liposomes using viral fusogenic proteins |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
baculovirus-expression system |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
extracellular vesicle |
| キーワード |
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|
主題Scheme |
Other |
|
主題 |
liposome |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
membrane fusion |
| キーワード |
|
|
主題Scheme |
UDC |
|
主題 |
single-particle analysis |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
viral fusogenic protein |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
| 著者 |
Ishikawa, Raga
吉田, 昭介
Sawada, Shin-ichi
Sasaki, Yoshihiro
Akiyoshi, Kazunari
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Extracellular vesicles (EVs) have potential biomedical applications, particularly as a means of transport for therapeutic agents. There is a need for rapid and efficient EV-liposome membrane fusion that maintains the integrity of hybrid EVs. We recently described Sf9 insect cell-derived EVs on which functional membrane proteins were presented using a baculovirus-expression system. Here, we developed hybrid EVs by membrane fusion of small liposomes and EVs equipped with baculoviral fusogenic proteins. Single-particle analysis of EV-liposome complexes revealed controlled introduction of liposome components into EVs. Our findings and methodology will support further applications of EV engineering in biomedicine. |
| 書誌情報 |
en : FEBS Open Bio
巻 12,
号 6,
p. 1178-1187,
発行日 2022-04-05
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| 出版者 |
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|
出版者 |
Wiley |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2211-5463 |
| 出版者版DOI |
|
|
関連タイプ |
isReplacedBy |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1002/2211-5463.13406 |
| 権利 |
|
|
権利情報Resource |
https://creativecommons.org/licenses/by/4.0/ |
|
権利情報 |
c 2022 The Authors. This is an open access article under the terms of the Creative Commons Attribution License, which permits use,distribution and reproduction in any medium, provided the original work is properly cited. |
| 著者版フラグ |
|
|
出版タイプ |
NA |
