| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-08-29 |
| タイトル |
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タイトル |
Electrochemical activities of Fe2O3-modified microelectrode for dopamine detection using fast-scan cyclic voltammetry |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
Sato, Nicha
Ohta, Yasumi
春田, 牧人
Takehara, Hironari
田代, 洋行
笹川, 清隆
Jongprateep, Oratai
太田, 淳
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Dopamine (DA) is the most important neurotransmitter involved in motor control. Abnormalities in neurotransmitter levels may indicate brain disorders, such as Parkinson’s disease and depression. Herein, electrochemical sensors containing metal oxide nanoparticles were fabricated for detecting DA. Specifically, iron oxide nanoparticles were applied onto a flexible polyimide substrate to obtain a flexible microelectrode and their DA detection performance was evaluated in vitro and in vivo. The electrochemical performance of the fabricated sensor was evaluated via fast-scan cyclic voltammetry conducted in a DA solution at concentrations between 0 and 50 nM. The peak current corresponding to the oxidation reaction of the Fe2O3-modified microelectrode for DA was observed at an applied potential of 0.49 V. The modified microelectrode exhibited a DA response with a high sensitivity of 34.14 nA/μm2 nM and a low limit of detection of 8.76 nM. In vivo experiments were performed using a freely moving mouse. Notably, 15 min after nicotine injection, the current increased considerably. The peak current corresponded to a 10 nM concentration in the calibration curve. The co-detection of DA and serotonin was also analyzed. The results showed that only the oxidation peak of DA appeared upon applying a triangular voltage waveform. Therefore, the proposed detector is capable of overcoming the drawbacks associated with conventional detectors and can be integrated with other implantable devices. |
| 書誌情報 |
en : AIP Advances
巻 13,
号 2,
発行日 2023-02-07
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| 出版者 |
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出版者 |
American Institute of Physics |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2158-3226 |
| 出版者版DOI |
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関連タイプ |
isReplacedBy |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1063/5.0123865 |
| 出版者版URI |
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関連タイプ |
isReplacedBy |
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識別子タイプ |
URI |
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関連識別子 |
https://pubs.aip.org/aip/adv/article/13/2/025026/2876933 |
| 権利 |
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権利情報Resource |
http://creativecommons.org/licenses/by/4.0/ |
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権利情報 |
$00A9 2023 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| 著者版フラグ |
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出版タイプ |
NA |
