| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-08-29 |
| タイトル |
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タイトル |
Implantable Multimodal Sensing Device for Simultaneous Imaging and Electrophysiological Recording of Mouse Brain Activity |
| 言語 |
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言語 |
eng |
| キーワード |
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主題Scheme |
Other |
|
主題 |
implantable device |
| キーワード |
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主題Scheme |
Other |
|
主題 |
multimodal sensor |
| キーワード |
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主題Scheme |
Other |
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主題 |
neural recording |
| キーワード |
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主題Scheme |
Other |
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主題 |
CMOS image sensor |
| 資源タイプ |
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資源タイプ |
research report |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
Sugie, Kenji
笹川, 清隆
Okada, Ryoma
Ohta, Yasumi
Takehara, Hironari
春田, 牧人
田代, 洋行
太田, 淳
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Optical and electrophysiological measurements help us understand mouse brain functions. One type of device available for optical measurements is an implantable complementary metal-oxide-semiconductor (CMOS) image sensor (ICIS). However, an ICIS alone cannot directly measure the electrical signals emitted by mouse brain neurons. Considering this limitation, we have developed an implantable multimodal sensor that can simultaneously make optical and electrophysiological measurements of the neural activity in the brains of mice. The proposed device integrates a CMOS image sensor and a neural amplifier with a recording electrode into a single chip, making it no more invasive than a conventional implantable CMOS image sensor. The proposed device is based on a 0.35-μm CMOS standard process and occupies an area of 0.50 × 5.0 mm2. Furthermore, a hybrid filter is fabricated on the imaging pixel array to remove the excitation light and selectively detect fluorescence. From electrophysiological measurements, we confirm that the neural amplifier features a mid-band gain of 39 dB from 500 mHz to 4 kHz, which is the bandwidth that includes local field and action potentials. Crosstalk noise is observed because of the digital signal used to control the image sensor. However, in vivo experiments demonstrate that the device is capable of simultaneously measuring and processing optical and electrophysiological signals when the amplitude spectrum has a peak of less than 1 μV. |
| 書誌情報 |
en : Sensors and Materials
巻 35,
号 9,
p. 3173-3188,
発行日 2023-09-28
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| 出版者 |
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出版者 |
MYU K.K. |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2435-0869 |
| 出版者版DOI |
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関連タイプ |
isReplacedBy |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.18494/SAM4264 |
| 出版者版URI |
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関連タイプ |
isReplacedBy |
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識別子タイプ |
URI |
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関連識別子 |
https://sensors.myu-group.co.jp/article.php?ss=4264 |
| 権利 |
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権利情報Resource |
http://creativecommons.org/licenses/by/4.0/ |
|
権利情報 |
Copyright(C) MYU K.K. This work is licensed under a Creative Commons Attribution 4.0 International License. |
| 著者版フラグ |
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出版タイプ |
NA |
