| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-08-08 |
| タイトル |
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タイトル |
Acquisition of neural fate by combination of BMP blockade and chromatin modification |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
Ong, Agnes Lee Chen
小鍛治, 俊也
Kishi, Arisa
Takihara, Yoshihiro
篠塚, 琢磨
Shimamoto, Ren
磯谷, 綾子
Shirai, Manabu
笹井, 紀明
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Neural induction is a process where naive cells are converted into committed cells with neural characteristics, and it occurs at the earliest step during embryogenesis. Although the signaling molecules and chromatin remodeling for neural induction have been identified, the mutual relationships between these molecules are yet to be fully understood. By taking advantage of the neural differentiation system of mouse embryonic stem (ES) cells, we discovered that the BMP signal regulates the expression of several polycomb repressor complex (PRC) component genes. We particularly focused on Polyhomeotic Homolog 1 (Phc1) and established Phc1-knockout (Phc1-KO) ES cells. We found that Phc1-KO failed to acquire the neural fate, and the cells remained in pluripotent or primitive non-neural states. Chromatin accessibility analysis suggests that Phc1 is essential for chromatin packing. Aberrant upregulation of the BMP signal was confirmed in the Phc1 homozygotic mutant embryos. Taken together, Phc1 is required for neural differentiation through epigenetic modification. |
| 書誌情報 |
en : iScience
巻 26,
号 10,
発行日 2023-10-20
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| 出版者 |
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出版者 |
Cell Press |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2589-0042 |
| 出版者版DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1016/j.isci.2023.107887 |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
URI |
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関連識別子 |
https://www.sciencedirect.com/science/article/pii/S2589004223019648 |
| 権利 |
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権利情報Resource |
http://creativecommons.org/licenses/by/4.0/ |
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権利情報 |
c 2023 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| 著者版フラグ |
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出版タイプ |
VoR |
fulltext (6.7 MB)
