| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-05-21 |
| タイトル |
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タイトル |
Theoretical model of membrane protrusions driven by curved active proteins |
| 言語 |
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言語 |
eng |
| キーワード |
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主題Scheme |
Other |
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主題 |
cell membrane |
| キーワード |
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主題Scheme |
Other |
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主題 |
curved inclusions |
| キーワード |
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主題Scheme |
Other |
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主題 |
Monte-Carlo simulations |
| キーワード |
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主題Scheme |
Other |
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主題 |
closed vesicle shapes |
| キーワード |
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主題Scheme |
Other |
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主題 |
cell motility |
| キーワード |
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主題Scheme |
Other |
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主題 |
filopodia |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
Ravid, Yoav
Peni$010D$2009, Samo
Mimori-Kiyosue, Yuko
末次, 志郎
Igli$010D, Ale$0161
Gov, Nir S.
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Eukaryotic cells intrinsically change their shape, by changing the composition of their membrane and by restructuring their underlying cytoskeleton. We present here further studies and extensions of a minimal physical model, describing a closed vesicle with mobile curved membrane protein complexes. The cytoskeletal forces describe the protrusive force due to actin polymerization which is recruited to the membrane by the curved protein complexes. We characterize the phase diagrams of this model, as function of the magnitude of the active forces, nearest-neighbor protein interactions and the proteins’ spontaneous curvature. It was previously shown that this model can explain the formation of lamellipodia-like flat protrusions, and here we explore the regimes where the model can also give rise to filopodia-like tubular protrusions. We extend the simulation with curved components of both convex and concave species, where we find the formation of complex ruffled clusters, as well as internalized invaginations that resemble the process of endocytosis and macropinocytosis. We alter the force model representing the cytoskeleton to simulate the effects of bundled instead of branched structure, resulting in shapes which resemble filopodia. |
| 書誌情報 |
en : Frontiers in Molecular Biosciences
巻 10,
発行日 2023-05-09
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| 出版者 |
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出版者 |
Frontiers Media |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2296-889X |
| 出版者版DOI |
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関連タイプ |
isReplacedBy |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.3389/fmolb.2023.1153420 |
| 出版者版URI |
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関連タイプ |
isReplacedBy |
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識別子タイプ |
URI |
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関連識別子 |
https://www.frontiersin.org/articles/10.3389/fmolb.2023.1153420/full |
| 権利 |
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権利情報Resource |
http://creativecommons.org/licenses/by/4.0/ |
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権利情報 |
$00A9 2023 Ravid, Peni$010D$2009, Mimori-Kiyosue, Suetsugu, Igli$010D and Gov. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| 著者版フラグ |
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出版タイプ |
NA |
