| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-05-16 |
| タイトル |
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タイトル |
Small GTPase Cdc42, WASP, and scaffold proteins for higher-order assembly of the F-BAR domain protein |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
| 著者 |
Wan Mohamad Noor, Wan Nurul Izzati
Nguyen, Nhung Thi Hong
Cheong, Theng Ho
Chek, Min Fey
箱嶋, 敏雄
Inaba, Takehiko
Hanawa-Suetsugu, Kyoko
西村, 珠子
末次, 志郎
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
The higher-order assembly of Bin-amphiphysin-Rvs (BAR) domain proteins, including the FCH-BAR (F-BAR) domain proteins, into lattice on the membrane is essential for the formation of subcellular structures. However, the regulation of their ordered assembly has not been elucidated. Here, we show that the higher ordered assembly of growth-arrested specific 7 (GAS7), an F-BAR domain protein, is regulated by the multivalent scaffold proteins of Wiskott-Aldrich syndrome protein (WASP)/neural WASP, that commonly binds to the BAR domain superfamily proteins, together with WISH, Nck, the activated small guanosine triphosphatase Cdc42, and a membrane-anchored phagocytic receptor. The assembly kinetics by fluorescence resonance energy transfer monitoring indicated that the GAS7 assembly on liposomes started within seconds and was further increased by the presence of these proteins. The regulated GAS7 assembly was abolished by Wiskott-Aldrich syndrome mutations both in vitro and in cellular phagocytosis. Therefore, Cdc42 and the scaffold proteins that commonly bind to the BAR domain superfamily proteins promoted GAS7 assembly. |
| 書誌情報 |
en : Science Advances
巻 9,
号 17,
発行日 2023-04-26
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| 出版者 |
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出版者 |
American Association for the Advancement of Science |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2375-2548 |
| 出版者版DOI |
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関連タイプ |
isReplacedBy |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1126/sciadv.adf5143 |
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関連タイプ |
isReplacedBy |
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識別子タイプ |
URI |
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関連識別子 |
https://www.science.org/doi/full/10.1126/sciadv.adf5143 |
| 権利 |
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権利情報Resource |
https://creativecommons.org/licenses/by/4.0/ |
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権利情報 |
$00A9 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). |
| 著者版フラグ |
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出版タイプ |
NA |
